Changes in cerebral blood flow, cerebral metabolites, and breathing movements in the sheep fetus following asphyxia produced by occlusion of the umbilical cord

Edwin BingBing Yan, Ana Aradhna Baburamani, Adrian Mark Walker, David William Walker

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

Severe global asphyxia, even if brief, results in prolonged cerebral hypoperfusion in fetal sheep. In this study we sought evidence to support the hypothesis that cerebral hypoperfusion is a consequence of suppressed cerebral metabolism. In the 24 h following complete occlusion of the umbilical cord for 10 min, sagittal sinus blood flow velocity was significantly decreased for up to 12 h. Capillary blood flow, measured using microspheres, decreased at 1 and 5 h after cord occlusion in many brain regions including cortical grey and white matter. Microdialysis probes implanted in the cerebral cortex revealed an increase in extracellular glucose concentrations in grey matter for 7-8 h post-asphyxia, while lactate increased only briefly, suggesting decreased cerebral glucose utilization over this time. While this data, and the concurrent suppression of breathing movements and electrocortical activity supports the concept of hypometabolic hypoperfusion, the significant increase of pyruvate and glycerol concentrations in dialysate fluid obtained from the cerebral cortex at 3-8 h after cord occlusion suggests an eventual loss of membrane integrity, and the prolonged increase of breathing movements for many hours suggests loss of the pontine/thalamic control that produces the distinct pattern of fetal breathing movements, in utero. Key words: cerebral blood flow, fetal asphyxia, fetal breathing movements, ceebral metabolism.
Original languageEnglish
Pages (from-to)R60 - R69
Number of pages10
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume297
Issue number1
DOIs
Publication statusPublished - 2009

Cite this

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title = "Changes in cerebral blood flow, cerebral metabolites, and breathing movements in the sheep fetus following asphyxia produced by occlusion of the umbilical cord",
abstract = "Severe global asphyxia, even if brief, results in prolonged cerebral hypoperfusion in fetal sheep. In this study we sought evidence to support the hypothesis that cerebral hypoperfusion is a consequence of suppressed cerebral metabolism. In the 24 h following complete occlusion of the umbilical cord for 10 min, sagittal sinus blood flow velocity was significantly decreased for up to 12 h. Capillary blood flow, measured using microspheres, decreased at 1 and 5 h after cord occlusion in many brain regions including cortical grey and white matter. Microdialysis probes implanted in the cerebral cortex revealed an increase in extracellular glucose concentrations in grey matter for 7-8 h post-asphyxia, while lactate increased only briefly, suggesting decreased cerebral glucose utilization over this time. While this data, and the concurrent suppression of breathing movements and electrocortical activity supports the concept of hypometabolic hypoperfusion, the significant increase of pyruvate and glycerol concentrations in dialysate fluid obtained from the cerebral cortex at 3-8 h after cord occlusion suggests an eventual loss of membrane integrity, and the prolonged increase of breathing movements for many hours suggests loss of the pontine/thalamic control that produces the distinct pattern of fetal breathing movements, in utero. Key words: cerebral blood flow, fetal asphyxia, fetal breathing movements, ceebral metabolism.",
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Changes in cerebral blood flow, cerebral metabolites, and breathing movements in the sheep fetus following asphyxia produced by occlusion of the umbilical cord. / Yan, Edwin BingBing; Baburamani, Ana Aradhna; Walker, Adrian Mark; Walker, David William.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 297, No. 1, 2009, p. R60 - R69.

Research output: Contribution to journalArticleResearchpeer-review

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AB - Severe global asphyxia, even if brief, results in prolonged cerebral hypoperfusion in fetal sheep. In this study we sought evidence to support the hypothesis that cerebral hypoperfusion is a consequence of suppressed cerebral metabolism. In the 24 h following complete occlusion of the umbilical cord for 10 min, sagittal sinus blood flow velocity was significantly decreased for up to 12 h. Capillary blood flow, measured using microspheres, decreased at 1 and 5 h after cord occlusion in many brain regions including cortical grey and white matter. Microdialysis probes implanted in the cerebral cortex revealed an increase in extracellular glucose concentrations in grey matter for 7-8 h post-asphyxia, while lactate increased only briefly, suggesting decreased cerebral glucose utilization over this time. While this data, and the concurrent suppression of breathing movements and electrocortical activity supports the concept of hypometabolic hypoperfusion, the significant increase of pyruvate and glycerol concentrations in dialysate fluid obtained from the cerebral cortex at 3-8 h after cord occlusion suggests an eventual loss of membrane integrity, and the prolonged increase of breathing movements for many hours suggests loss of the pontine/thalamic control that produces the distinct pattern of fetal breathing movements, in utero. Key words: cerebral blood flow, fetal asphyxia, fetal breathing movements, ceebral metabolism.

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