Changes in brainstem and spinal adrenoceptor binding with ageing in spontaneously hypertensive and Wistar-Kyoto rats

L. G. Howes, R. J. Summers

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Adrenoceptor binding in membranes prepared from the brainstem and thoracic spinal cord of male spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats aged 6 and 36-40 weeks has been compared. Binding of [3H]prazosin (α1-receptors), [3H]rauwolscine (α2-receptors) and [3H]dihydroalprenolol (DHA: β-receptors) fell with age in both regions in both strains. Strain, independent of age, was also a significant determinant of binding for all three ligands in brainstem and for [3H]DHA in spinal cord. The changes in receptor binding may reflect differences in noradrenergic activity with age and between SHR and WKY rats.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalNeuroscience Letters
Volume57
Issue number3
DOIs
Publication statusPublished - 24 Jun 1985

Keywords

  • adrenoceptor binding
  • aging
  • hypertension
  • rat

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