Change to either a nonandrogenic or androgenic progestin-containing oral contraceptive preparation is associated with improved sexual function in women with oral contraceptive-associated sexual dysfunction

Susan Ruth Davis, Johannes Bitzer, Annamaria Giraldi, Santiago Palacios, Susanne Parke, Marco Serrani, Uwe Mellinger, Rossella Nappi

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38 Citations (Scopus)

Abstract

Introduction: It is a commonly held belief that combined oral contraceptive (COC) pills containing an androgenic progestin may be less likely to impair sexual function than COCs containing an anti-androgenic progestin. Aim: The study aims to compare the effects of a COC containing a progestin with an anti-androgenic profile (estradiol valerate [E2V]/dienogest [DNG]) to that of one with an androgenic progestin (ethinyl estradiol [EE]/levonorgestrel [LNG]) on sexual function in women with COC-associated sexual dysfunction. Methods: In this multicenter, randomized, double-blind, noninferiority study, women with COC-associated female sexual dysfunction (FSD) were randomized to E2V/DNG or EE/LNG for six cycles. The primary outcome was the change in the sum of Female Sexual Function Index (FSFI) desire and arousal component scores between baseline and cycle 6. Secondary outcome measures included changes to the FSFI domains, the Female Sexual Distress Scale (FSDS-R), Vaginal Health Assessment, the Atrophy Symptom Questionnaire, and the Psychological General Well Being Index over six treatment cycles. Main Outcome Measure: The main outcome is the change in the sum of FSFI desire and arousal component scores between baseline and cycle 6. Results: Of 276 women screened, 213 received treatment and 191 completed the study. The mean increase in the sum of FSFI desire and arousal component scores was 5.90 (standard deviation [SD] 5.45) for E2V/DNG and 5.79 (SD 6.17) for EE/LNG (change from baseline P
Original languageEnglish
Pages (from-to)3069 - 3079
Number of pages11
JournalThe Journal of Sexual Medicine
Volume10
Issue number12
DOIs
Publication statusPublished - 2013

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