@article{9b0df7c6b5f843d4a8bcb5d5af2f4597,
title = "Challenges in diagnosis and understanding of natural history of polycystic ovary syndrome",
abstract = "Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting 8\%–13\% of reproductive-aged women. The aetiology of the syndrome is complex, with genetic susceptibility, androgen exposure in early life and adiposity related dysfunction leading to perturbance in hypothalamic–ovarian function. PCOS clinical features are heterogeneous, with manifestations arising even in early adolescence, developing into multisystem reproductive, metabolic and psychological manifestations in adulthood. In this review, we will discuss challenges in the diagnosis of PCOS and understanding of the natural history of PCOS.",
keywords = "challenges, diagnosis, natural history, phenotypes, polycystic ovary syndrome",
author = "Joham, \{Anju E.\} and Terhi Piltonen and Lujan, \{Marla E.\} and Sylvia Kiconco and Tay, \{Chau Thien\}",
note = "Funding Information: Open access publishing facilitated by Monash University, as part of the Wiley - Monash University agreement via the Council of Australian University Librarians. Funding Information: The first attempt to define PCOS occurred in an expert conference in 1990 sponsored in part by the National Institute of Child Health and Human Development of the United States (US) National Institutes of Health (NIH). After a survey of all participants, mainly from US, regarding their perception of PCOS features, they concluded PCOS as an androgen‐excess disorder of exclusion with ovarian consequences. The 1990 NIH criteria therefore defines PCOS as the presence of both clinical and/or biochemical HA and ovulatory dysfunction (OD). Using the criteria, PCOS prevalence is estimated to be between 5\% and 8\%, raising worldwide recognition for PCOS to be the most prevalent endocrinopathy in women of reproductive age. While the diagnostic criteria were driven mainly by expert consensus rather than research evidence, it sets the scene for much of the subsequent literature, which contributes greatly to our current understanding of PCOS. 19 19 19 1 Publisher Copyright: {\textcopyright} 2022 The Authors. Clinical Endocrinology published by John Wiley \& Sons Ltd.",
year = "2022",
month = aug,
doi = "10.1111/cen.14757",
language = "English",
volume = "97",
pages = "165--173",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "Wiley-Blackwell",
number = "2",
}
SDG 3 Good Health and Well-being