Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland

Findings from an International Workshop

Christos Nikolaidis, Chang Ming, Carla Pedrazzani, Tina Van Der Horst, Andrea Kaiser-Grolimund, Zanfina Ademi, Rosmarie Bührer-Landolt, Nicole Bürki, Maria Caiata-Zufferey, Victoria Champion, Pierre O. Chappuis, Carmen Kohler, Tobias E. Erlanger, Rossella Graffeo, Heather Hampel, Karl Heinimann, Viola Heinzelmann-Schwarz, Christian Kurzeder, Christian Monnerat, Laurel L. Northouse & 10 others Olivia Pagani, Nicole Probst-Hensch, Manuela Rabaglio, Eveline Schoenau, Eric J.G. Sijbrands, Monika Taborelli, Corinne Urech, Valeria Viassolo, Simon Wieser, Maria C. Katapodi

Research output: Contribution to journalArticleOtherpeer-review

Abstract

Background: An international workshop on cancer predisposition cascade genetic screening for hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) took place in Switzerland, with leading researchers and clinicians in cascade screening and hereditary cancer from different disciplines. The purpose of the workshop was to enhance the implementation of cascade genetic screening in Switzerland. Participants discussed the challenges and opportunities associated with cascade screening for HBOC and LS in Switzerland (CASCADE study); family implications and the need for family-based interventions; the need to evaluate the cost-effectiveness of cascade genetic screening; and interprofessional collaboration needed to lead this initiative. Methods: The workshop aims were achieved through exchange of data and experiences from successful cascade screening programs in the Netherlands, Australia, and the state of Ohio, USA; Swiss-based studies and scientific experience that support cancer cascade screening in Switzerland; programs of research in psychosocial oncology and family-based studies; data from previous cost-effectiveness analyses of cascade genetic screening in the Netherlands and in Australia; and organizational experience from a large interprofessional collaborative. Scientific presentations were recorded and discussions were synthesized to present the workshop findings. Results: The key elements of successful implementation of cascade genetic screening are a supportive network of stakeholders and connection to complementary initiatives; sample size and recruitment of relatives; centralized organization of services; data-based cost-effectiveness analyses; transparent organization of the initiative; and continuous funding. Conclusions: This paper describes the processes and key findings of an international workshop on cancer predisposition cascade screening, which will guide the CASCADE study in Switzerland.

Original languageEnglish
Pages (from-to)121-132
Number of pages12
JournalPublic Health Genomics
Volume21
Issue number3-4
DOIs
Publication statusPublished - 2018

Keywords

  • Cascade genetic screening
  • Hereditary breast and ovarian cancer
  • Implementation science
  • Lynch syndrome
  • Public health genetics

Cite this

Nikolaidis, Christos ; Ming, Chang ; Pedrazzani, Carla ; Van Der Horst, Tina ; Kaiser-Grolimund, Andrea ; Ademi, Zanfina ; Bührer-Landolt, Rosmarie ; Bürki, Nicole ; Caiata-Zufferey, Maria ; Champion, Victoria ; Chappuis, Pierre O. ; Kohler, Carmen ; Erlanger, Tobias E. ; Graffeo, Rossella ; Hampel, Heather ; Heinimann, Karl ; Heinzelmann-Schwarz, Viola ; Kurzeder, Christian ; Monnerat, Christian ; Northouse, Laurel L. ; Pagani, Olivia ; Probst-Hensch, Nicole ; Rabaglio, Manuela ; Schoenau, Eveline ; Sijbrands, Eric J.G. ; Taborelli, Monika ; Urech, Corinne ; Viassolo, Valeria ; Wieser, Simon ; Katapodi, Maria C. / Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland : Findings from an International Workshop. In: Public Health Genomics. 2018 ; Vol. 21, No. 3-4. pp. 121-132.
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title = "Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland: Findings from an International Workshop",
abstract = "Background: An international workshop on cancer predisposition cascade genetic screening for hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) took place in Switzerland, with leading researchers and clinicians in cascade screening and hereditary cancer from different disciplines. The purpose of the workshop was to enhance the implementation of cascade genetic screening in Switzerland. Participants discussed the challenges and opportunities associated with cascade screening for HBOC and LS in Switzerland (CASCADE study); family implications and the need for family-based interventions; the need to evaluate the cost-effectiveness of cascade genetic screening; and interprofessional collaboration needed to lead this initiative. Methods: The workshop aims were achieved through exchange of data and experiences from successful cascade screening programs in the Netherlands, Australia, and the state of Ohio, USA; Swiss-based studies and scientific experience that support cancer cascade screening in Switzerland; programs of research in psychosocial oncology and family-based studies; data from previous cost-effectiveness analyses of cascade genetic screening in the Netherlands and in Australia; and organizational experience from a large interprofessional collaborative. Scientific presentations were recorded and discussions were synthesized to present the workshop findings. Results: The key elements of successful implementation of cascade genetic screening are a supportive network of stakeholders and connection to complementary initiatives; sample size and recruitment of relatives; centralized organization of services; data-based cost-effectiveness analyses; transparent organization of the initiative; and continuous funding. Conclusions: This paper describes the processes and key findings of an international workshop on cancer predisposition cascade screening, which will guide the CASCADE study in Switzerland.",
keywords = "Cascade genetic screening, Hereditary breast and ovarian cancer, Implementation science, Lynch syndrome, Public health genetics",
author = "Christos Nikolaidis and Chang Ming and Carla Pedrazzani and {Van Der Horst}, Tina and Andrea Kaiser-Grolimund and Zanfina Ademi and Rosmarie B{\"u}hrer-Landolt and Nicole B{\"u}rki and Maria Caiata-Zufferey and Victoria Champion and Chappuis, {Pierre O.} and Carmen Kohler and Erlanger, {Tobias E.} and Rossella Graffeo and Heather Hampel and Karl Heinimann and Viola Heinzelmann-Schwarz and Christian Kurzeder and Christian Monnerat and Northouse, {Laurel L.} and Olivia Pagani and Nicole Probst-Hensch and Manuela Rabaglio and Eveline Schoenau and Sijbrands, {Eric J.G.} and Monika Taborelli and Corinne Urech and Valeria Viassolo and Simon Wieser and Katapodi, {Maria C.}",
year = "2018",
doi = "10.1159/000496495",
language = "English",
volume = "21",
pages = "121--132",
journal = "Public Health Genomics",
issn = "1662-4246",
publisher = "Karger",
number = "3-4",

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Nikolaidis, C, Ming, C, Pedrazzani, C, Van Der Horst, T, Kaiser-Grolimund, A, Ademi, Z, Bührer-Landolt, R, Bürki, N, Caiata-Zufferey, M, Champion, V, Chappuis, PO, Kohler, C, Erlanger, TE, Graffeo, R, Hampel, H, Heinimann, K, Heinzelmann-Schwarz, V, Kurzeder, C, Monnerat, C, Northouse, LL, Pagani, O, Probst-Hensch, N, Rabaglio, M, Schoenau, E, Sijbrands, EJG, Taborelli, M, Urech, C, Viassolo, V, Wieser, S & Katapodi, MC 2018, 'Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland: Findings from an International Workshop', Public Health Genomics, vol. 21, no. 3-4, pp. 121-132. https://doi.org/10.1159/000496495

Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland : Findings from an International Workshop. / Nikolaidis, Christos; Ming, Chang; Pedrazzani, Carla; Van Der Horst, Tina; Kaiser-Grolimund, Andrea; Ademi, Zanfina; Bührer-Landolt, Rosmarie; Bürki, Nicole; Caiata-Zufferey, Maria; Champion, Victoria; Chappuis, Pierre O.; Kohler, Carmen; Erlanger, Tobias E.; Graffeo, Rossella; Hampel, Heather; Heinimann, Karl; Heinzelmann-Schwarz, Viola; Kurzeder, Christian; Monnerat, Christian; Northouse, Laurel L.; Pagani, Olivia; Probst-Hensch, Nicole; Rabaglio, Manuela; Schoenau, Eveline; Sijbrands, Eric J.G.; Taborelli, Monika; Urech, Corinne; Viassolo, Valeria; Wieser, Simon; Katapodi, Maria C.

In: Public Health Genomics, Vol. 21, No. 3-4, 2018, p. 121-132.

Research output: Contribution to journalArticleOtherpeer-review

TY - JOUR

T1 - Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland

T2 - Findings from an International Workshop

AU - Nikolaidis, Christos

AU - Ming, Chang

AU - Pedrazzani, Carla

AU - Van Der Horst, Tina

AU - Kaiser-Grolimund, Andrea

AU - Ademi, Zanfina

AU - Bührer-Landolt, Rosmarie

AU - Bürki, Nicole

AU - Caiata-Zufferey, Maria

AU - Champion, Victoria

AU - Chappuis, Pierre O.

AU - Kohler, Carmen

AU - Erlanger, Tobias E.

AU - Graffeo, Rossella

AU - Hampel, Heather

AU - Heinimann, Karl

AU - Heinzelmann-Schwarz, Viola

AU - Kurzeder, Christian

AU - Monnerat, Christian

AU - Northouse, Laurel L.

AU - Pagani, Olivia

AU - Probst-Hensch, Nicole

AU - Rabaglio, Manuela

AU - Schoenau, Eveline

AU - Sijbrands, Eric J.G.

AU - Taborelli, Monika

AU - Urech, Corinne

AU - Viassolo, Valeria

AU - Wieser, Simon

AU - Katapodi, Maria C.

PY - 2018

Y1 - 2018

N2 - Background: An international workshop on cancer predisposition cascade genetic screening for hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) took place in Switzerland, with leading researchers and clinicians in cascade screening and hereditary cancer from different disciplines. The purpose of the workshop was to enhance the implementation of cascade genetic screening in Switzerland. Participants discussed the challenges and opportunities associated with cascade screening for HBOC and LS in Switzerland (CASCADE study); family implications and the need for family-based interventions; the need to evaluate the cost-effectiveness of cascade genetic screening; and interprofessional collaboration needed to lead this initiative. Methods: The workshop aims were achieved through exchange of data and experiences from successful cascade screening programs in the Netherlands, Australia, and the state of Ohio, USA; Swiss-based studies and scientific experience that support cancer cascade screening in Switzerland; programs of research in psychosocial oncology and family-based studies; data from previous cost-effectiveness analyses of cascade genetic screening in the Netherlands and in Australia; and organizational experience from a large interprofessional collaborative. Scientific presentations were recorded and discussions were synthesized to present the workshop findings. Results: The key elements of successful implementation of cascade genetic screening are a supportive network of stakeholders and connection to complementary initiatives; sample size and recruitment of relatives; centralized organization of services; data-based cost-effectiveness analyses; transparent organization of the initiative; and continuous funding. Conclusions: This paper describes the processes and key findings of an international workshop on cancer predisposition cascade screening, which will guide the CASCADE study in Switzerland.

AB - Background: An international workshop on cancer predisposition cascade genetic screening for hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) took place in Switzerland, with leading researchers and clinicians in cascade screening and hereditary cancer from different disciplines. The purpose of the workshop was to enhance the implementation of cascade genetic screening in Switzerland. Participants discussed the challenges and opportunities associated with cascade screening for HBOC and LS in Switzerland (CASCADE study); family implications and the need for family-based interventions; the need to evaluate the cost-effectiveness of cascade genetic screening; and interprofessional collaboration needed to lead this initiative. Methods: The workshop aims were achieved through exchange of data and experiences from successful cascade screening programs in the Netherlands, Australia, and the state of Ohio, USA; Swiss-based studies and scientific experience that support cancer cascade screening in Switzerland; programs of research in psychosocial oncology and family-based studies; data from previous cost-effectiveness analyses of cascade genetic screening in the Netherlands and in Australia; and organizational experience from a large interprofessional collaborative. Scientific presentations were recorded and discussions were synthesized to present the workshop findings. Results: The key elements of successful implementation of cascade genetic screening are a supportive network of stakeholders and connection to complementary initiatives; sample size and recruitment of relatives; centralized organization of services; data-based cost-effectiveness analyses; transparent organization of the initiative; and continuous funding. Conclusions: This paper describes the processes and key findings of an international workshop on cancer predisposition cascade screening, which will guide the CASCADE study in Switzerland.

KW - Cascade genetic screening

KW - Hereditary breast and ovarian cancer

KW - Implementation science

KW - Lynch syndrome

KW - Public health genetics

UR - http://www.scopus.com/inward/record.url?scp=85060979221&partnerID=8YFLogxK

U2 - 10.1159/000496495

DO - 10.1159/000496495

M3 - Article

VL - 21

SP - 121

EP - 132

JO - Public Health Genomics

JF - Public Health Genomics

SN - 1662-4246

IS - 3-4

ER -