CGRP/adrenomedullin

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)

Abstract

Calcitonin-gene-related peptide (CGRP) and adrenomedullin (AM), two structurally related peptides, are synthesized and secreted by many mammalian tissues, including the central nervous system. The two peptides, which were initially described as vasodilators, are now considered as multifunctional regulatory agents. Their cellular actions are mediated by pharmacologically distinct receptors, each comprising two subunits: a classic 7 transmembrane spanning G protein-coupled receptor (GPCR) and one of 3 single transmembrane spanning accessory receptor activity modifying proteins (RAMP). Two GPCRs?the calcitonin receptor (CTR) and calcitonin-receptor-like receptor (CLR)?contribute to CGRP/AM receptor phenotypes. In the brain, CGRP and AM are widely expressed and, in addition to their vasodilator effect, activate several autonomic centers involved in the regulation of fluid and electrolyte balance. Additionally, they have modulatory effects on the synthesis and release of several other neuropeptides and have neuroprotective roles. The potent vasodilator activity of CGRP in cerebral microvasculature is possibly relevant to the pathology of migraine.
Original languageEnglish
Title of host publicationHandbook of Biologically Active Peptides
EditorsAbba J Kastin
Place of PublicationSan Diego CA USA
PublisherElsevier
Pages744 - 751
Number of pages8
EditionSecond Edition
ISBN (Print)9780123850959
DOIs
Publication statusPublished - 2013

Cite this

Wootten, D. L., Tilakaratne, N., Christopoulos, A., & Sexton, P. (2013). CGRP/adrenomedullin. In A. J. Kastin (Ed.), Handbook of Biologically Active Peptides (Second Edition ed., pp. 744 - 751). San Diego CA USA: Elsevier. https://doi.org/10.1016/B978-0-12-385095-9.00100-7
Wootten, Denise Laura ; Tilakaratne, Nandasena ; Christopoulos, Arthur ; Sexton, Patrick. / CGRP/adrenomedullin. Handbook of Biologically Active Peptides. editor / Abba J Kastin. Second Edition. ed. San Diego CA USA : Elsevier, 2013. pp. 744 - 751
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Wootten, DL, Tilakaratne, N, Christopoulos, A & Sexton, P 2013, CGRP/adrenomedullin. in AJ Kastin (ed.), Handbook of Biologically Active Peptides. Second Edition edn, Elsevier, San Diego CA USA, pp. 744 - 751. https://doi.org/10.1016/B978-0-12-385095-9.00100-7

CGRP/adrenomedullin. / Wootten, Denise Laura; Tilakaratne, Nandasena; Christopoulos, Arthur; Sexton, Patrick.

Handbook of Biologically Active Peptides. ed. / Abba J Kastin. Second Edition. ed. San Diego CA USA : Elsevier, 2013. p. 744 - 751.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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T1 - CGRP/adrenomedullin

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N2 - Calcitonin-gene-related peptide (CGRP) and adrenomedullin (AM), two structurally related peptides, are synthesized and secreted by many mammalian tissues, including the central nervous system. The two peptides, which were initially described as vasodilators, are now considered as multifunctional regulatory agents. Their cellular actions are mediated by pharmacologically distinct receptors, each comprising two subunits: a classic 7 transmembrane spanning G protein-coupled receptor (GPCR) and one of 3 single transmembrane spanning accessory receptor activity modifying proteins (RAMP). Two GPCRs?the calcitonin receptor (CTR) and calcitonin-receptor-like receptor (CLR)?contribute to CGRP/AM receptor phenotypes. In the brain, CGRP and AM are widely expressed and, in addition to their vasodilator effect, activate several autonomic centers involved in the regulation of fluid and electrolyte balance. Additionally, they have modulatory effects on the synthesis and release of several other neuropeptides and have neuroprotective roles. The potent vasodilator activity of CGRP in cerebral microvasculature is possibly relevant to the pathology of migraine.

AB - Calcitonin-gene-related peptide (CGRP) and adrenomedullin (AM), two structurally related peptides, are synthesized and secreted by many mammalian tissues, including the central nervous system. The two peptides, which were initially described as vasodilators, are now considered as multifunctional regulatory agents. Their cellular actions are mediated by pharmacologically distinct receptors, each comprising two subunits: a classic 7 transmembrane spanning G protein-coupled receptor (GPCR) and one of 3 single transmembrane spanning accessory receptor activity modifying proteins (RAMP). Two GPCRs?the calcitonin receptor (CTR) and calcitonin-receptor-like receptor (CLR)?contribute to CGRP/AM receptor phenotypes. In the brain, CGRP and AM are widely expressed and, in addition to their vasodilator effect, activate several autonomic centers involved in the regulation of fluid and electrolyte balance. Additionally, they have modulatory effects on the synthesis and release of several other neuropeptides and have neuroprotective roles. The potent vasodilator activity of CGRP in cerebral microvasculature is possibly relevant to the pathology of migraine.

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Wootten DL, Tilakaratne N, Christopoulos A, Sexton P. CGRP/adrenomedullin. In Kastin AJ, editor, Handbook of Biologically Active Peptides. Second Edition ed. San Diego CA USA: Elsevier. 2013. p. 744 - 751 https://doi.org/10.1016/B978-0-12-385095-9.00100-7