Abstract
| Original language | English |
|---|---|
| Title of host publication | Handbook of Biologically Active Peptides |
| Editors | Abba J Kastin |
| Place of Publication | San Diego CA USA |
| Publisher | Elsevier |
| Pages | 744 - 751 |
| Number of pages | 8 |
| Edition | Second Edition |
| ISBN (Print) | 9780123850959 |
| DOIs | |
| Publication status | Published - 2013 |
Cite this
}
CGRP/adrenomedullin. / Wootten, Denise Laura; Tilakaratne, Nandasena; Christopoulos, Arthur; Sexton, Patrick.
Handbook of Biologically Active Peptides. ed. / Abba J Kastin. Second Edition. ed. San Diego CA USA : Elsevier, 2013. p. 744 - 751.Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review
TY - CHAP
T1 - CGRP/adrenomedullin
AU - Wootten, Denise Laura
AU - Tilakaratne, Nandasena
AU - Christopoulos, Arthur
AU - Sexton, Patrick
PY - 2013
Y1 - 2013
N2 - Calcitonin-gene-related peptide (CGRP) and adrenomedullin (AM), two structurally related peptides, are synthesized and secreted by many mammalian tissues, including the central nervous system. The two peptides, which were initially described as vasodilators, are now considered as multifunctional regulatory agents. Their cellular actions are mediated by pharmacologically distinct receptors, each comprising two subunits: a classic 7 transmembrane spanning G protein-coupled receptor (GPCR) and one of 3 single transmembrane spanning accessory receptor activity modifying proteins (RAMP). Two GPCRs?the calcitonin receptor (CTR) and calcitonin-receptor-like receptor (CLR)?contribute to CGRP/AM receptor phenotypes. In the brain, CGRP and AM are widely expressed and, in addition to their vasodilator effect, activate several autonomic centers involved in the regulation of fluid and electrolyte balance. Additionally, they have modulatory effects on the synthesis and release of several other neuropeptides and have neuroprotective roles. The potent vasodilator activity of CGRP in cerebral microvasculature is possibly relevant to the pathology of migraine.
AB - Calcitonin-gene-related peptide (CGRP) and adrenomedullin (AM), two structurally related peptides, are synthesized and secreted by many mammalian tissues, including the central nervous system. The two peptides, which were initially described as vasodilators, are now considered as multifunctional regulatory agents. Their cellular actions are mediated by pharmacologically distinct receptors, each comprising two subunits: a classic 7 transmembrane spanning G protein-coupled receptor (GPCR) and one of 3 single transmembrane spanning accessory receptor activity modifying proteins (RAMP). Two GPCRs?the calcitonin receptor (CTR) and calcitonin-receptor-like receptor (CLR)?contribute to CGRP/AM receptor phenotypes. In the brain, CGRP and AM are widely expressed and, in addition to their vasodilator effect, activate several autonomic centers involved in the regulation of fluid and electrolyte balance. Additionally, they have modulatory effects on the synthesis and release of several other neuropeptides and have neuroprotective roles. The potent vasodilator activity of CGRP in cerebral microvasculature is possibly relevant to the pathology of migraine.
UR - http://www.sciencedirect.com/science/article/pii/B9780123850959001007?via=ihub#
U2 - 10.1016/B978-0-12-385095-9.00100-7
DO - 10.1016/B978-0-12-385095-9.00100-7
M3 - Chapter (Book)
SN - 9780123850959
SP - 744
EP - 751
BT - Handbook of Biologically Active Peptides
A2 - Kastin, Abba J
PB - Elsevier
CY - San Diego CA USA
ER -