CGMP matters

Barbara Kemp-Harper, Robert Feil

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Abstract

The second messenger cyclic guanosine 3′,5′-monophosphate (cGMP) controls many cellular functions ranging from growth to contractility. Generated from guanylyl cyclases in response to natriuretic peptides or nitric oxide, cGMP transduces its effects through a number of cGMP effectors, including cGMP-regulated phosphodiesterases and protein kinases. Drugs that modulate cGMP levels are emerging as promising therapies, particularly for cardiovascular disorders. This report summarizes new data on the molecular mechanisms, (patho)physiological relevance, and therapeutic potential of the cGMP signaling system that were presented at the 3rd cGMP meeting held in June 2007 in Dresden, Germany.

Original languageEnglish
Article number19pe12
JournalScience Signaling
Volume1
Issue number9
DOIs
Publication statusPublished - 4 Mar 2008

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