CFD-DEM study the effect of carrier-drug mass ratio on the aerosolisation process in original and modified dry powder inhalers

Zhenbo Tong; Wenqi Zhong; Aibing Yu

doi:10.1007/978-981-10-1926-5_100

CFD-DEM study the effect of carrier-drug mass ratio on the aerosolisation process in original and modified dry powder inhalers

Zhenbo Tong, Wenqi Zhong, Aibing Yu

Chemical & Biological Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

4 Citations (Scopus)

Abstract

Previous studies have reported that carrier-drug mass ratio has a significant influence on the aerosol performance of dry powder inhalation systems. This paper investigated the effect of carrier-drug mass ratio in different inhaler designs based on a multi-scale modelling technique combined computational fluid dynamics (CFD) and discrete element method (DEM) approach, aiming to develop better understanding of the aerosolisation mechanism of carrier-based formulation. Different formulations containing drug (salbutamol sulphate) and carrier (lactose) were used in experimental and numerical works with varied carrier-drug mass ratios ranging from 1:10 to 1:200. The fine particle fractions (FPFs) in the original and cross grid inhaler-throat model were measured to characterize the aerosolisation performance. The dynamics of the carrier particles in the original and cross grid inhaler-throat model were simulated. The experimental results showed that the significant difference between the original and cross-grid design for the pure drug but not for the carrier system. The numerical results showed that there was no much different in FPFs until a critical threshold was exceeded when the drug loading increased

Original language	English
Title of host publication	Proceedings of the 7th International Conference on Discrete Element Methods
Editors	Xikui Li, Yuntian Feng, Graham Mustoe
Place of Publication	Singapore, Singapore
Publisher	Springer
Pages	957-965
Number of pages	9
ISBN (Electronic)	9789811019265
ISBN (Print)	9789811019258
DOIs	https://doi.org/10.1007/978-981-10-1926-5_100
Publication status	Published - 2017
Event	International Conference on Discrete Element Methods 2016 - Dalian University of Technology, Dalian, China Duration: 1 Aug 2016 → 4 Aug 2016 Conference number: 7th https://link.springer.com/book/10.1007/978-981-10-1926-5

Publication series

Name	Springer proceedings in physics
Publisher	Springer
Volume	188
ISSN (Print)	0930-8989
ISSN (Electronic)	1867-4941

Conference

Conference	International Conference on Discrete Element Methods 2016
Abbreviated title	DEM 2016
Country/Territory	China
City	Dalian
Period	1/08/16 → 4/08/16
Internet address	https://link.springer.com/book/10.1007/978-981-10-1926-5

Access to Document

10.1007/978-981-10-1926-5_100

Cite this

Tong, Z., Zhong, W., & Yu, A. (2017). CFD-DEM study the effect of carrier-drug mass ratio on the aerosolisation process in original and modified dry powder inhalers. In X. Li, Y. Feng, & G. Mustoe (Eds.), Proceedings of the 7th International Conference on Discrete Element Methods (pp. 957-965). (Springer proceedings in physics; Vol. 188). Springer. https://doi.org/10.1007/978-981-10-1926-5_100

Tong, Zhenbo ; Zhong, Wenqi ; Yu, Aibing. / CFD-DEM study the effect of carrier-drug mass ratio on the aerosolisation process in original and modified dry powder inhalers. Proceedings of the 7th International Conference on Discrete Element Methods. editor / Xikui Li ; Yuntian Feng ; Graham Mustoe. Singapore, Singapore : Springer, 2017. pp. 957-965 (Springer proceedings in physics).

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title = "CFD-DEM study the effect of carrier-drug mass ratio on the aerosolisation process in original and modified dry powder inhalers",

abstract = "Previous studies have reported that carrier-drug mass ratio has a significant influence on the aerosol performance of dry powder inhalation systems. This paper investigated the effect of carrier-drug mass ratio in different inhaler designs based on a multi-scale modelling technique combined computational fluid dynamics (CFD) and discrete element method (DEM) approach, aiming to develop better understanding of the aerosolisation mechanism of carrier-based formulation. Different formulations containing drug (salbutamol sulphate) and carrier (lactose) were used in experimental and numerical works with varied carrier-drug mass ratios ranging from 1:10 to 1:200. The fine particle fractions (FPFs) in the original and cross grid inhaler-throat model were measured to characterize the aerosolisation performance. The dynamics of the carrier particles in the original and cross grid inhaler-throat model were simulated. The experimental results showed that the significant difference between the original and cross-grid design for the pure drug but not for the carrier system. The numerical results showed that there was no much different in FPFs until a critical threshold was exceeded when the drug loading increased",

author = "Zhenbo Tong and Wenqi Zhong and Aibing Yu",

year = "2017",

doi = "10.1007/978-981-10-1926-5_100",

language = "English",

isbn = "9789811019258",

series = "Springer proceedings in physics",

publisher = "Springer",

pages = "957--965",

editor = "Xikui Li and Feng, {Yuntian } and Graham Mustoe",

booktitle = "Proceedings of the 7th International Conference on Discrete Element Methods",

note = "International Conference on Discrete Element Methods 2016, DEM 2016 ; Conference date: 01-08-2016 Through 04-08-2016",

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Tong, Z, Zhong, W & Yu, A 2017, CFD-DEM study the effect of carrier-drug mass ratio on the aerosolisation process in original and modified dry powder inhalers. in X Li, Y Feng & G Mustoe (eds), Proceedings of the 7th International Conference on Discrete Element Methods. Springer proceedings in physics, vol. 188, Springer, Singapore, Singapore, pp. 957-965, International Conference on Discrete Element Methods 2016, Dalian, China, 1/08/16. https://doi.org/10.1007/978-981-10-1926-5_100

CFD-DEM study the effect of carrier-drug mass ratio on the aerosolisation process in original and modified dry powder inhalers. / Tong, Zhenbo; Zhong, Wenqi; Yu, Aibing.
Proceedings of the 7th International Conference on Discrete Element Methods. ed. / Xikui Li; Yuntian Feng; Graham Mustoe. Singapore, Singapore: Springer, 2017. p. 957-965 (Springer proceedings in physics; Vol. 188).

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

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PY - 2017

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N2 - Previous studies have reported that carrier-drug mass ratio has a significant influence on the aerosol performance of dry powder inhalation systems. This paper investigated the effect of carrier-drug mass ratio in different inhaler designs based on a multi-scale modelling technique combined computational fluid dynamics (CFD) and discrete element method (DEM) approach, aiming to develop better understanding of the aerosolisation mechanism of carrier-based formulation. Different formulations containing drug (salbutamol sulphate) and carrier (lactose) were used in experimental and numerical works with varied carrier-drug mass ratios ranging from 1:10 to 1:200. The fine particle fractions (FPFs) in the original and cross grid inhaler-throat model were measured to characterize the aerosolisation performance. The dynamics of the carrier particles in the original and cross grid inhaler-throat model were simulated. The experimental results showed that the significant difference between the original and cross-grid design for the pure drug but not for the carrier system. The numerical results showed that there was no much different in FPFs until a critical threshold was exceeded when the drug loading increased

AB - Previous studies have reported that carrier-drug mass ratio has a significant influence on the aerosol performance of dry powder inhalation systems. This paper investigated the effect of carrier-drug mass ratio in different inhaler designs based on a multi-scale modelling technique combined computational fluid dynamics (CFD) and discrete element method (DEM) approach, aiming to develop better understanding of the aerosolisation mechanism of carrier-based formulation. Different formulations containing drug (salbutamol sulphate) and carrier (lactose) were used in experimental and numerical works with varied carrier-drug mass ratios ranging from 1:10 to 1:200. The fine particle fractions (FPFs) in the original and cross grid inhaler-throat model were measured to characterize the aerosolisation performance. The dynamics of the carrier particles in the original and cross grid inhaler-throat model were simulated. The experimental results showed that the significant difference between the original and cross-grid design for the pure drug but not for the carrier system. The numerical results showed that there was no much different in FPFs until a critical threshold was exceeded when the drug loading increased

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Tong Z, Zhong W, Yu A. CFD-DEM study the effect of carrier-drug mass ratio on the aerosolisation process in original and modified dry powder inhalers. In Li X, Feng Y, Mustoe G, editors, Proceedings of the 7th International Conference on Discrete Element Methods. Singapore, Singapore: Springer. 2017. p. 957-965. (Springer proceedings in physics). doi: 10.1007/978-981-10-1926-5_100