CFD-DEM study the effect of carrier-drug mass ratio on the aerosolisation process in original and modified dry powder inhalers

Zhenbo Tong, Wenqi Zhong, Aibing Yu

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1 Citation (Scopus)

Abstract

Previous studies have reported that carrier-drug mass ratio has a significant influence on the aerosol performance of dry powder inhalation systems. This paper investigated the effect of carrier-drug mass ratio in different inhaler designs based on a multi-scale modelling technique combined computational fluid dynamics (CFD) and discrete element method (DEM) approach, aiming to develop better understanding of the aerosolisation mechanism of carrier-based formulation. Different formulations containing drug (salbutamol sulphate) and carrier (lactose) were used in experimental and numerical works with varied carrier-drug mass ratios ranging from 1:10 to 1:200. The fine particle fractions (FPFs) in the original and cross grid inhaler-throat model were measured to characterize the aerosolisation performance. The dynamics of the carrier particles in the original and cross grid inhaler-throat model were simulated. The experimental results showed that the significant difference between the original and cross-grid design for the pure drug but not for the carrier system. The numerical results showed that there was no much different in FPFs until a critical threshold was exceeded when the drug loading increased
Original languageEnglish
Title of host publicationProceedings of the 7th International Conference on Discrete Element Methods
EditorsXikui Li, Yuntian Feng, Graham Mustoe
Place of PublicationSingapore, Singapore
PublisherSpringer
Pages957-965
Number of pages9
ISBN (Electronic)9789811019265
ISBN (Print)9789811019258
DOIs
Publication statusPublished - 2017
EventInternational Conference on Discrete Element Methods 2016 - Dalian University of Technology, Dalian, China
Duration: 1 Aug 20164 Aug 2016
Conference number: 7th
https://link.springer.com/book/10.1007/978-981-10-1926-5

Publication series

NameSpringer proceedings in physics
PublisherSpringer
Volume188
ISSN (Print)0930-8989
ISSN (Electronic)1867-4941

Conference

ConferenceInternational Conference on Discrete Element Methods 2016
Abbreviated titleDEM 2016
CountryChina
CityDalian
Period1/08/164/08/16
Internet address

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