CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance

Sarah M. Turpin-Nolan, Philipp Hammerschmidt, Weiyi Chen, Alexander Jais, Katharina Timper, Motoharu Awazawa, Susanne Brodesser, Jens C. Brüning

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52 Citations (Scopus)

Abstract

Skeletal muscle ceramide accumulation has recently been implicated in the pathogenesis of insulin resistance. Turpin-Nolan et al. demonstrate that deletion of ceramide synthase 1, and the consequent reduction of C18:0 acyl-chain ceramide specifically in skeletal muscle, enhances whole-body glucose metabolism in obesity through increased muscle-derived circulating Fgf21 concentrations.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalCell Reports
Volume26
Issue number1
DOIs
Publication statusPublished - 2 Jan 2019
Externally publishedYes

Keywords

  • ceramide
  • ceramide synthase 1
  • CerS1
  • diabetes mellitus
  • FGF-21
  • insulin resistance
  • obesity
  • skeletal muscle
  • sphingolipids

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