CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance

Sarah M. Turpin-Nolan; Philipp Hammerschmidt; Weiyi Chen; Alexander Jais; Katharina Timper; Motoharu Awazawa; Susanne Brodesser; Jens C. Brüning

doi:10.1016/j.celrep.2018.12.031

CerS1-Derived C_18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance

Sarah M. Turpin-Nolan, Philipp Hammerschmidt, Weiyi Chen, Alexander Jais, Katharina Timper, Motoharu Awazawa, Susanne Brodesser, Jens C. Brüning

Research output: Contribution to journal › Article › Research › peer-review

52 Citations (Scopus)

Abstract

Skeletal muscle ceramide accumulation has recently been implicated in the pathogenesis of insulin resistance. Turpin-Nolan et al. demonstrate that deletion of ceramide synthase 1, and the consequent reduction of C_18:0 acyl-chain ceramide specifically in skeletal muscle, enhances whole-body glucose metabolism in obesity through increased muscle-derived circulating Fgf21 concentrations.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Cell Reports
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2018.12.031
Publication status	Published - 2 Jan 2019
Externally published	Yes

Keywords

ceramide
ceramide synthase 1
CerS1
diabetes mellitus
FGF-21
insulin resistance
obesity
skeletal muscle
sphingolipids

Access to Document

10.1016/j.celrep.2018.12.031

262864396-oaFinal published version, 2.17 MBLicence: CC BY-NC-ND

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Cite this

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title = "CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance",

abstract = "Skeletal muscle ceramide accumulation has recently been implicated in the pathogenesis of insulin resistance. Turpin-Nolan et al. demonstrate that deletion of ceramide synthase 1, and the consequent reduction of C18:0 acyl-chain ceramide specifically in skeletal muscle, enhances whole-body glucose metabolism in obesity through increased muscle-derived circulating Fgf21 concentrations.",

keywords = "ceramide, ceramide synthase 1, CerS1, diabetes mellitus, FGF-21, insulin resistance, obesity, skeletal muscle, sphingolipids",

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CerS1-Derived C_18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance. / Turpin-Nolan, Sarah M.; Hammerschmidt, Philipp; Chen, Weiyi; Jais, Alexander; Timper, Katharina; Awazawa, Motoharu; Brodesser, Susanne; Brüning, Jens C.

In: Cell Reports, Vol. 26, No. 1, 02.01.2019, p. 1-7.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Jais, Alexander

AU - Timper, Katharina

AU - Awazawa, Motoharu

AU - Brodesser, Susanne

AU - Brüning, Jens C.

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