Cerebral oxygenation during subclinical seizures in neonatal hypoxic-ischaemic encephalopathy

Research output: Contribution to journalArticleOther

6 Citations (Scopus)

Abstract

Treatment of subclinical seizures in newborn HIE remains a contentious issue, especially in light of potential adverse effects of aggressive use of anticonvulsants. We report on the association of subclinical seizures with changes in cerebral oxygenation in an infant with HIE. Our results show that subclinical seizures of longer durations and with associated autonomic disturbance (increased blood pressure) are more likely to be associated with fluctuation in cerebral oxygenation, with some seizures resulting in cerebral hypoxia. Future studies should aim to delineate the effects of subclinical seizure and anticonvulsant treatment on cerebral oxygenation, and their relationships to developmental outcome. Level of cerebral oxygenation may play a role in refining anti-convulsant treatment and management of subclinical seizures in newborns.
Original languageEnglish
Pages (from-to)304 - 307
Number of pages4
JournalEuropean Journal of Paediatric Neurology
Volume16
Issue number3
DOIs
Publication statusPublished - 2012

Cite this

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title = "Cerebral oxygenation during subclinical seizures in neonatal hypoxic-ischaemic encephalopathy",
abstract = "Treatment of subclinical seizures in newborn HIE remains a contentious issue, especially in light of potential adverse effects of aggressive use of anticonvulsants. We report on the association of subclinical seizures with changes in cerebral oxygenation in an infant with HIE. Our results show that subclinical seizures of longer durations and with associated autonomic disturbance (increased blood pressure) are more likely to be associated with fluctuation in cerebral oxygenation, with some seizures resulting in cerebral hypoxia. Future studies should aim to delineate the effects of subclinical seizure and anticonvulsant treatment on cerebral oxygenation, and their relationships to developmental outcome. Level of cerebral oxygenation may play a role in refining anti-convulsant treatment and management of subclinical seizures in newborns.",
author = "Reshma Silas and Arvind Sehgal and Adrian Walker and Flora Wong",
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Cerebral oxygenation during subclinical seizures in neonatal hypoxic-ischaemic encephalopathy. / Silas, Reshma; Sehgal, Arvind; Walker, Adrian; Wong, Flora.

In: European Journal of Paediatric Neurology, Vol. 16, No. 3, 2012, p. 304 - 307.

Research output: Contribution to journalArticleOther

TY - JOUR

T1 - Cerebral oxygenation during subclinical seizures in neonatal hypoxic-ischaemic encephalopathy

AU - Silas, Reshma

AU - Sehgal, Arvind

AU - Walker, Adrian

AU - Wong, Flora

PY - 2012

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N2 - Treatment of subclinical seizures in newborn HIE remains a contentious issue, especially in light of potential adverse effects of aggressive use of anticonvulsants. We report on the association of subclinical seizures with changes in cerebral oxygenation in an infant with HIE. Our results show that subclinical seizures of longer durations and with associated autonomic disturbance (increased blood pressure) are more likely to be associated with fluctuation in cerebral oxygenation, with some seizures resulting in cerebral hypoxia. Future studies should aim to delineate the effects of subclinical seizure and anticonvulsant treatment on cerebral oxygenation, and their relationships to developmental outcome. Level of cerebral oxygenation may play a role in refining anti-convulsant treatment and management of subclinical seizures in newborns.

AB - Treatment of subclinical seizures in newborn HIE remains a contentious issue, especially in light of potential adverse effects of aggressive use of anticonvulsants. We report on the association of subclinical seizures with changes in cerebral oxygenation in an infant with HIE. Our results show that subclinical seizures of longer durations and with associated autonomic disturbance (increased blood pressure) are more likely to be associated with fluctuation in cerebral oxygenation, with some seizures resulting in cerebral hypoxia. Future studies should aim to delineate the effects of subclinical seizure and anticonvulsant treatment on cerebral oxygenation, and their relationships to developmental outcome. Level of cerebral oxygenation may play a role in refining anti-convulsant treatment and management of subclinical seizures in newborns.

UR - http://www.sciencedirect.com/science/article/pii/S1090379811001899

U2 - 10.1016/j.ejpn.2011.09.003

DO - 10.1016/j.ejpn.2011.09.003

M3 - Article

VL - 16

SP - 304

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JO - European Journal of Paediatric Neurology

JF - European Journal of Paediatric Neurology

SN - 1090-3798

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