Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 304 - 307 |
| Number of pages | 4 |
| Journal | European Journal of Paediatric Neurology |
| Volume | 16 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2012 |
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Cerebral oxygenation during subclinical seizures in neonatal hypoxic-ischaemic encephalopathy. / Silas, Reshma; Sehgal, Arvind; Walker, Adrian; Wong, Flora.
In: European Journal of Paediatric Neurology, Vol. 16, No. 3, 2012, p. 304 - 307.Research output: Contribution to journal › Article › Other
TY - JOUR
T1 - Cerebral oxygenation during subclinical seizures in neonatal hypoxic-ischaemic encephalopathy
AU - Silas, Reshma
AU - Sehgal, Arvind
AU - Walker, Adrian
AU - Wong, Flora
PY - 2012
Y1 - 2012
N2 - Treatment of subclinical seizures in newborn HIE remains a contentious issue, especially in light of potential adverse effects of aggressive use of anticonvulsants. We report on the association of subclinical seizures with changes in cerebral oxygenation in an infant with HIE. Our results show that subclinical seizures of longer durations and with associated autonomic disturbance (increased blood pressure) are more likely to be associated with fluctuation in cerebral oxygenation, with some seizures resulting in cerebral hypoxia. Future studies should aim to delineate the effects of subclinical seizure and anticonvulsant treatment on cerebral oxygenation, and their relationships to developmental outcome. Level of cerebral oxygenation may play a role in refining anti-convulsant treatment and management of subclinical seizures in newborns.
AB - Treatment of subclinical seizures in newborn HIE remains a contentious issue, especially in light of potential adverse effects of aggressive use of anticonvulsants. We report on the association of subclinical seizures with changes in cerebral oxygenation in an infant with HIE. Our results show that subclinical seizures of longer durations and with associated autonomic disturbance (increased blood pressure) are more likely to be associated with fluctuation in cerebral oxygenation, with some seizures resulting in cerebral hypoxia. Future studies should aim to delineate the effects of subclinical seizure and anticonvulsant treatment on cerebral oxygenation, and their relationships to developmental outcome. Level of cerebral oxygenation may play a role in refining anti-convulsant treatment and management of subclinical seizures in newborns.
UR - http://www.sciencedirect.com/science/article/pii/S1090379811001899
U2 - 10.1016/j.ejpn.2011.09.003
DO - 10.1016/j.ejpn.2011.09.003
M3 - Article
VL - 16
SP - 304
EP - 307
JO - European Journal of Paediatric Neurology
JF - European Journal of Paediatric Neurology
SN - 1090-3798
IS - 3
ER -