Centromere protein b-null mice display decreasing reproductive performance through successive generations of breeding due to diminishing endometrial glands

Kerry J. Fowler, L. H. Wong, B. K. Griffiths, M. C. Sibson, S. Reed, K. H A Choo

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4 Citations (Scopus)

Abstract

Centromere protein B is a highly conserved constitutive protein found at centromeres. Gene knockout studies in mice have unexpectedly identified Cenpb as a candidate gene involved in uterine function. The present study further explores the role of Cenpb in mice by intermating Cenpb-null mice over several generations. Breeding studies and analysis of uterine tissue indicate that Cenpb-null mice lose reproductive fitness over a number of generations due to a significant reduction in endometrial glands. These results suggest that Cenpb may play an important function in the short- and long-term maintenance of uterine integrity.

Original languageEnglish
Pages (from-to)367-377
Number of pages11
JournalReproduction
Volume127
Issue number3
Publication statusPublished - Mar 2004
Externally publishedYes

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