Central nervous system control of cough: Pharmacological implications

Stuart B Mazzone, Alice E McGovern, Leonie J Cole, Michael J Farrell

Research output: Contribution to journalReview ArticleResearchpeer-review

12 Citations (Scopus)


For many years the idea of a cough center in the brain dominated discussions in the field without any substantial progress in defining what this cough center is or how it functions. Substantial progress has now been made and many of the central neural elements involved in coughing are being described. Furthermore, hypothesis driven research into the function of these neural elements is providing exciting new leads for possible therapeutic targets. The concept of a specific, centrally acting drug for cough suppression is fast becoming a reality. This review summarizes the key findings from the past few years and provides a perspective on future directions for the development of novel antitussives. 

Original languageEnglish
Pages (from-to)265-271
Number of pages7
JournalCurrent Opinion in Pharmacology
Issue number3
Publication statusPublished - Jun 2011
Externally publishedYes

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