Central nervous system binding sites for calcitonin and calcitonin gene-related peptide

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Abstract

Alternative splicing of the primary RNA transcript of the calcitonin gene leads to the generation of two distinct peptides, calcitonin (CT) and calcitonin gene-related peptide (CGRP). These peptides share only limited sequence homology and generally subserve different biological functions through their own distinct binding sites, which differ in specificity and distribution. Additionally, a binding site with high-affinity binding for both peptides that has a restricted pattern of distribution has been identified. The present article reviews the biochemical and morphological characteristics of central CT and CGRP binding, sites.

Original languageEnglish
Pages (from-to)251-273
Number of pages23
JournalMolecular Neurobiology
Volume5
Issue number2-4
DOIs
Publication statusPublished - 1 Jun 1991
Externally publishedYes

Keywords

  • autoradiography
  • binding site
  • Calcitonin
  • calcitonin gene-related peptide
  • nervous system
  • receptor

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