Central and peripheral neuroimmune responses: hyporesponsiveness during pregnancy

Sarah Spencer, Abdeslam Mouihate, Michael A Galic, Quentin J Pittman

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)


There are periods in the life of a healthy animal (including humans) when the febrile response to an immune challenge is suppressed. One such period is during late pregnancy, particularly around the time of parturition. In the 30 or so years since this febrile hyporesponsiveness was first noted, much work has been done to investigate the mechanisms and adaptive significance of this phenomenon. In this review we present some insight into how and why the body deliberately re-programmes itself to develop smaller fevers in response to an immune challenge and therefore to be potentially less successful at fighting infection.
Original languageEnglish
Pages (from-to)399 - 406
Number of pages8
JournalThe Journal of Physiology
Issue number2
Publication statusPublished - 2008
Externally publishedYes

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