Abstract
Harnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in tumor medicine, as many tumors express specific tumor associated antigens that are recognized by the adaptive immune system. CD8 T cells have direct cytolytic activity against tumor cells, and CD4 T cells mount a variety of responses that have important influences on tumor growth. We discuss how individual T-cell subsets contribute to antitumor responses and the goals and problems associated with generating and/or maintaining effective multifunctional T-cell responses to provide long-term protection against tumors.
Original language | English |
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Pages (from-to) | 97-126 |
Number of pages | 30 |
Journal | Critical Reviews in Immunology |
Volume | 32 |
Issue number | 2 |
Publication status | Published - 2012 |
Externally published | Yes |
Keywords
- Adoptive cell therapy
- Cancer
- Immunotherapy
- Memory T cells
- Self-renewal
- T-cell differentiation