Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens

Stefano Caserta, Jessica Geraldine Borger, Rose Zamoyska

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Abstract

Harnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in tumor medicine, as many tumors express specific tumor associated antigens that are recognized by the adaptive immune system. CD8 T cells have direct cytolytic activity against tumor cells, and CD4 T cells mount a variety of responses that have important influences on tumor growth. We discuss how individual T-cell subsets contribute to antitumor responses and the goals and problems associated with generating and/or maintaining effective multifunctional T-cell responses to provide long-term protection against tumors.

Original languageEnglish
Pages (from-to)97-126
Number of pages30
JournalCritical Reviews in Immunology
Volume32
Issue number2
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Adoptive cell therapy
  • Cancer
  • Immunotherapy
  • Memory T cells
  • Self-renewal
  • T-cell differentiation

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