Central administration of the CNTF analogue, axokine, does not play a role in long-term energy homeostasis in adult mice

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Abstract

Background/Aims: Ciliary neurotrophic factor (CNTF) exerts powerful anorectic effects and has been suggested to regulate long-term energy balance by inducing adult neurogenesis in the arcuate nucleus of the hypothalamus. Methods: The CNTF analogue, Axokine, was administered into the lateral ventricle of high-fat fed mice for one week. Food intake, energy expenditure, body mass, glucose metabolism and neurogenesis in the arcuate nucleus (ARC) of the hypothalamus were assessed three weeks after cessation of Axokine treatment. Results: Short-term administration of Axokine induced an anorexic response but did not promote sustained weight loss. Instead, a rapid rebound in food intake and body mass occurred immediately after cessation of Axokine treatment and this tended to reduce insulin sensitivity. Immunolabeling of BrdU revealed limited neurogenesis in the ARC three weeks after Axokine treatment. Conclusion: These findings suggest that Axokine/CNTF does not induce substantial or sustained ARC neurogenesis or contribute to the long-term regulation of energy balance in mice.
Original languageEnglish
Pages (from-to)223-229
Number of pages7
JournalNeuroendocrinology
Volume103
Issue number3-4
DOIs
Publication statusPublished - May 2016

Keywords

  • arcuate nucleus
  • neurogenesis
  • food intake
  • energy balance
  • ciliary neurotrophic factor
  • insulin sensitivity

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