Cellulose nanocrystal (CNC)-stabilized Pickering emulsion for improved curcumin storage stability

Yuan Zhe Aw; Hui Peng Lim; Liang Ee Low; Charanjit Kaur Surjit Singh; Eng Seng Chan; Beng Ti Tey

doi:10.1016/j.lwt.2022.113249

Cellulose nanocrystal (CNC)-stabilized Pickering emulsion for improved curcumin storage stability

Yuan Zhe Aw, Hui Peng Lim, Liang Ee Low, Charanjit Kaur Surjit Singh, Eng Seng Chan, Beng Ti Tey

Research output: Contribution to journal › Article › Research › peer-review

45 Citations (Scopus)

Abstract

Curcumin is a bioactive supplement known to have many medical benefits. However, it has low bioavailability due to its insolubility in aqueous solution and rapid degradation profile. In this paper, an oil-in-water (O/W) Pickering emulsion (PE) was fabricated ultrasonically with different cellulose nanocrystal (CNC) concentrations to investigate its effect on the physicochemical properties of PE and the storage stability of curcumin. The CNC-PE produced remained stable for at least one month. The highest encapsulation efficiency of curcumin in CNC-PE was found to exceed 99%. For storage of curcumin containing CNC-PE under dark conditions, good stability of curcumin was observed with a half-life of 98.47 d, reflecting a nearly 20-fold improvement as compared to other existing PE systems. On the other hand, storage under visible light, UV light, and at elevated temperature (50 °C) increased the degradation rate of encapsulated curcumin following the order: 50 °C > UV light > visible light > dark. Our findings elucidated the promising potential of CNC-PE as a food-safe delivery system for sensitive lipophilic bioactive compounds.

Original language	English
Article number	113249
Number of pages	10
Journal	LWT
Volume	159
DOIs	https://doi.org/10.1016/j.lwt.2022.113249
Publication status	Published - 1 Apr 2022

Keywords

Cellulose nanocrystal
Curcumin
Encapsulation
Pickering emulsion
Storage stability

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378984742-oaFinal published version, 6.9 MBLicence: CC BY

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title = "Cellulose nanocrystal (CNC)-stabilized Pickering emulsion for improved curcumin storage stability",

abstract = "Curcumin is a bioactive supplement known to have many medical benefits. However, it has low bioavailability due to its insolubility in aqueous solution and rapid degradation profile. In this paper, an oil-in-water (O/W) Pickering emulsion (PE) was fabricated ultrasonically with different cellulose nanocrystal (CNC) concentrations to investigate its effect on the physicochemical properties of PE and the storage stability of curcumin. The CNC-PE produced remained stable for at least one month. The highest encapsulation efficiency of curcumin in CNC-PE was found to exceed 99%. For storage of curcumin containing CNC-PE under dark conditions, good stability of curcumin was observed with a half-life of 98.47 d, reflecting a nearly 20-fold improvement as compared to other existing PE systems. On the other hand, storage under visible light, UV light, and at elevated temperature (50 °C) increased the degradation rate of encapsulated curcumin following the order: 50 °C > UV light > visible light > dark. Our findings elucidated the promising potential of CNC-PE as a food-safe delivery system for sensitive lipophilic bioactive compounds.",

keywords = "Cellulose nanocrystal, Curcumin, Encapsulation, Pickering emulsion, Storage stability",

author = "Aw, {Yuan Zhe} and Lim, {Hui Peng} and Low, {Liang Ee} and {Surjit Singh}, {Charanjit Kaur} and Chan, {Eng Seng} and Tey, {Beng Ti}",

note = "Funding Information: The authors would like to thank the School of Engineering, Monash University Malaysia , for providing the Master studentship for Aw Yuan Zhe. This study was funded by FRGS Grant (FRGS/1/2020/STG01/MUSM/01/1) from Ministry of Higher Education, Malaysia . Funding Information: The authors would like to thank the School of Engineering, Monash University Malaysia, for providing the Master studentship for Aw Yuan Zhe. This study was funded by FRGS Grant (FRGS/1/2020/STG01/MUSM/01/1) from Ministry of Higher Education, Malaysia. Publisher Copyright: {\textcopyright} 2022 The Authors",

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T1 - Cellulose nanocrystal (CNC)-stabilized Pickering emulsion for improved curcumin storage stability

AU - Aw, Yuan Zhe

AU - Lim, Hui Peng

AU - Low, Liang Ee

AU - Surjit Singh, Charanjit Kaur

AU - Chan, Eng Seng

AU - Tey, Beng Ti

N1 - Funding Information: The authors would like to thank the School of Engineering, Monash University Malaysia , for providing the Master studentship for Aw Yuan Zhe. This study was funded by FRGS Grant (FRGS/1/2020/STG01/MUSM/01/1) from Ministry of Higher Education, Malaysia . Funding Information: The authors would like to thank the School of Engineering, Monash University Malaysia, for providing the Master studentship for Aw Yuan Zhe. This study was funded by FRGS Grant (FRGS/1/2020/STG01/MUSM/01/1) from Ministry of Higher Education, Malaysia. Publisher Copyright: © 2022 The Authors

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Curcumin is a bioactive supplement known to have many medical benefits. However, it has low bioavailability due to its insolubility in aqueous solution and rapid degradation profile. In this paper, an oil-in-water (O/W) Pickering emulsion (PE) was fabricated ultrasonically with different cellulose nanocrystal (CNC) concentrations to investigate its effect on the physicochemical properties of PE and the storage stability of curcumin. The CNC-PE produced remained stable for at least one month. The highest encapsulation efficiency of curcumin in CNC-PE was found to exceed 99%. For storage of curcumin containing CNC-PE under dark conditions, good stability of curcumin was observed with a half-life of 98.47 d, reflecting a nearly 20-fold improvement as compared to other existing PE systems. On the other hand, storage under visible light, UV light, and at elevated temperature (50 °C) increased the degradation rate of encapsulated curcumin following the order: 50 °C > UV light > visible light > dark. Our findings elucidated the promising potential of CNC-PE as a food-safe delivery system for sensitive lipophilic bioactive compounds.

AB - Curcumin is a bioactive supplement known to have many medical benefits. However, it has low bioavailability due to its insolubility in aqueous solution and rapid degradation profile. In this paper, an oil-in-water (O/W) Pickering emulsion (PE) was fabricated ultrasonically with different cellulose nanocrystal (CNC) concentrations to investigate its effect on the physicochemical properties of PE and the storage stability of curcumin. The CNC-PE produced remained stable for at least one month. The highest encapsulation efficiency of curcumin in CNC-PE was found to exceed 99%. For storage of curcumin containing CNC-PE under dark conditions, good stability of curcumin was observed with a half-life of 98.47 d, reflecting a nearly 20-fold improvement as compared to other existing PE systems. On the other hand, storage under visible light, UV light, and at elevated temperature (50 °C) increased the degradation rate of encapsulated curcumin following the order: 50 °C > UV light > visible light > dark. Our findings elucidated the promising potential of CNC-PE as a food-safe delivery system for sensitive lipophilic bioactive compounds.

KW - Cellulose nanocrystal

KW - Curcumin

KW - Encapsulation

KW - Pickering emulsion

KW - Storage stability

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U2 - 10.1016/j.lwt.2022.113249

DO - 10.1016/j.lwt.2022.113249

M3 - Article

AN - SCOPUS:85124989201

SN - 0023-6438

VL - 159

JO - LWT

JF - LWT

M1 - 113249

ER -

Cellulose nanocrystal (CNC)-stabilized Pickering emulsion for improved curcumin storage stability

Abstract

Keywords

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