Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides

Anouk von Borstel, Jan Stephan Sanders, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are systemic autoimmune diseases characterized by necrotizing inflammation of small- to medium-sized blood vessels, affecting primarily the lungs and kidneys. Both animal and human studies show that the balance between inflammatory- and regulatory T- and B cells determines the AAV disease pathogenesis. Recent evidence shows malfunctioning of the regulatory lymphocyte compartment in AAV. In this review we summarize the immune regulatory properties of both T- and B cells in patients with AAV and discuss how aberrations herein might contribute to the disease pathogenesis.

Original languageEnglish
Pages (from-to)413-421
Number of pages9
JournalAutoimmunity Reviews
Volume17
Issue number4
DOIs
Publication statusPublished - 1 Apr 2018
Externally publishedYes

Keywords

  • ANCA
  • B regulatory cells
  • T regulatory cells
  • Vasculitides

Cite this

von Borstel, A., Sanders, J. S., Rutgers, A., Stegeman, C. A., Heeringa, P., & Abdulahad, W. H. (2018). Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides. Autoimmunity Reviews, 17(4), 413-421. https://doi.org/10.1016/j.autrev.2017.12.002
von Borstel, Anouk ; Sanders, Jan Stephan ; Rutgers, Abraham ; Stegeman, Coen A. ; Heeringa, Peter ; Abdulahad, Wayel H. / Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides. In: Autoimmunity Reviews. 2018 ; Vol. 17, No. 4. pp. 413-421.
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von Borstel, A, Sanders, JS, Rutgers, A, Stegeman, CA, Heeringa, P & Abdulahad, WH 2018, 'Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides', Autoimmunity Reviews, vol. 17, no. 4, pp. 413-421. https://doi.org/10.1016/j.autrev.2017.12.002

Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides. / von Borstel, Anouk; Sanders, Jan Stephan; Rutgers, Abraham; Stegeman, Coen A.; Heeringa, Peter; Abdulahad, Wayel H.

In: Autoimmunity Reviews, Vol. 17, No. 4, 01.04.2018, p. 413-421.

Research output: Contribution to journalReview ArticleResearchpeer-review

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AU - Sanders, Jan Stephan

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AU - Abdulahad, Wayel H.

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