Cellular association and cargo release of redox-responsive polymer capsules mediated by exofacial thiols

Yan Yan, Yajun Wang, Joan Heath, Edouard Nice, Frank Caruso

Research output: Contribution to journalArticleResearchpeer-review

83 Citations (Scopus)

Abstract

Redox-responsive polymer capsules stabilized by disulfide bonds and loaded with hydrophobic cargo are prepared by templating mesoporous silica particles via layer-by-layer assembly. The thiols and disulfide bonds in the capsules interact with the exofacial thiols on the cell membrane, which regulate cellular association and cargo release from the capsules.
Original languageEnglish
Pages (from-to)3916 - 3921
Number of pages6
JournalAdvanced Materials
Volume23
Issue number34
DOIs
Publication statusPublished - 2011

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