Cellular association and cargo release of redox-responsive polymer capsules mediated by exofacial thiols

Yan Yan; Yajun Wang; Joan Heath; Edouard Nice; Frank Caruso

doi:10.1002/adma.201101609

Cellular association and cargo release of redox-responsive polymer capsules mediated by exofacial thiols

Yan Yan, Yajun Wang, Joan Heath, Edouard Nice, Frank Caruso

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › Research › peer-review

95 Citations (Scopus)

Abstract

Redox-responsive polymer capsules stabilized by disulfide bonds and loaded with hydrophobic cargo are prepared by templating mesoporous silica particles via layer-by-layer assembly. The thiols and disulfide bonds in the capsules interact with the exofacial thiols on the cell membrane, which regulate cellular association and cargo release from the capsules.

Original language	English
Pages (from-to)	3916 - 3921
Number of pages	6
Journal	Advanced Materials
Volume	23
Issue number	34
DOIs	https://doi.org/10.1002/adma.201101609
Publication status	Published - 2011

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10.1002/adma.201101609

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title = "Cellular association and cargo release of redox-responsive polymer capsules mediated by exofacial thiols",

abstract = "Redox-responsive polymer capsules stabilized by disulfide bonds and loaded with hydrophobic cargo are prepared by templating mesoporous silica particles via layer-by-layer assembly. The thiols and disulfide bonds in the capsules interact with the exofacial thiols on the cell membrane, which regulate cellular association and cargo release from the capsules.",

author = "Yan Yan and Yajun Wang and Joan Heath and Edouard Nice and Frank Caruso",

year = "2011",

doi = "10.1002/adma.201101609",

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T1 - Cellular association and cargo release of redox-responsive polymer capsules mediated by exofacial thiols

AU - Yan, Yan

AU - Wang, Yajun

AU - Heath, Joan

AU - Nice, Edouard

AU - Caruso, Frank

PY - 2011

Y1 - 2011

N2 - Redox-responsive polymer capsules stabilized by disulfide bonds and loaded with hydrophobic cargo are prepared by templating mesoporous silica particles via layer-by-layer assembly. The thiols and disulfide bonds in the capsules interact with the exofacial thiols on the cell membrane, which regulate cellular association and cargo release from the capsules.

AB - Redox-responsive polymer capsules stabilized by disulfide bonds and loaded with hydrophobic cargo are prepared by templating mesoporous silica particles via layer-by-layer assembly. The thiols and disulfide bonds in the capsules interact with the exofacial thiols on the cell membrane, which regulate cellular association and cargo release from the capsules.

UR - http://onlinelibrary.wiley.com/doi/10.1002/adma.201101609/pdf

U2 - 10.1002/adma.201101609

DO - 10.1002/adma.201101609

M3 - Article

SN - 0935-9648

VL - 23

SP - 3916

EP - 3921

JO - Advanced Materials

JF - Advanced Materials

IS - 34

ER -

Cellular association and cargo release of redox-responsive polymer capsules mediated by exofacial thiols

Abstract

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