Cellular and molecular determinants of normal and abnormal kidney development

Ming S. Tham, Ian M. Smyth

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Kidneys are bilateral organs required to maintain homeostasis in the body through the regulation of fluid composition and the excretion of metabolic waste products. The initial steps in organ development are characterized by cellular interactions which regulate both the position and number of kidneys formed. Once established, further development is driven by orchestrated interactions between progenitor cell populations which serve to establish both nephrons—the functional unit of the organ which filters the blood—and the complex ramified collecting duct system which transports urine to the bladder. The delicate balance involved in these processes is reflected in the emerging family of genetic or environmental factors which, when perturbed, give rise to defects in organ development or function later in life. This article is categorized under: Vertebrate Organogenesis > From a Tubular Primordium: Branched Birth Defects > Organ Anomalies.

Original languageEnglish
Article numbere338
Number of pages16
JournalWiley Interdisciplinary Reviews: Developmental Biology
Volume8
Issue number2
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • branching morphogenesis
  • congenital abnormalities of the kidneys and urinary tract
  • kidney development

Cite this

@article{8259127767dc4889b04a5c46c7d82d40,
title = "Cellular and molecular determinants of normal and abnormal kidney development",
abstract = "Kidneys are bilateral organs required to maintain homeostasis in the body through the regulation of fluid composition and the excretion of metabolic waste products. The initial steps in organ development are characterized by cellular interactions which regulate both the position and number of kidneys formed. Once established, further development is driven by orchestrated interactions between progenitor cell populations which serve to establish both nephrons—the functional unit of the organ which filters the blood—and the complex ramified collecting duct system which transports urine to the bladder. The delicate balance involved in these processes is reflected in the emerging family of genetic or environmental factors which, when perturbed, give rise to defects in organ development or function later in life. This article is categorized under: Vertebrate Organogenesis > From a Tubular Primordium: Branched Birth Defects > Organ Anomalies.",
keywords = "branching morphogenesis, congenital abnormalities of the kidneys and urinary tract, kidney development",
author = "Tham, {Ming S.} and Smyth, {Ian M.}",
year = "2019",
month = "3",
day = "1",
doi = "10.1002/wdev.338",
language = "English",
volume = "8",
journal = "Wiley Interdisciplinary Reviews: Developmental Biology",
issn = "1759-7684",
publisher = "John Wiley & Sons",
number = "2",

}

Cellular and molecular determinants of normal and abnormal kidney development. / Tham, Ming S.; Smyth, Ian M.

In: Wiley Interdisciplinary Reviews: Developmental Biology, Vol. 8, No. 2, e338, 01.03.2019.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Cellular and molecular determinants of normal and abnormal kidney development

AU - Tham, Ming S.

AU - Smyth, Ian M.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Kidneys are bilateral organs required to maintain homeostasis in the body through the regulation of fluid composition and the excretion of metabolic waste products. The initial steps in organ development are characterized by cellular interactions which regulate both the position and number of kidneys formed. Once established, further development is driven by orchestrated interactions between progenitor cell populations which serve to establish both nephrons—the functional unit of the organ which filters the blood—and the complex ramified collecting duct system which transports urine to the bladder. The delicate balance involved in these processes is reflected in the emerging family of genetic or environmental factors which, when perturbed, give rise to defects in organ development or function later in life. This article is categorized under: Vertebrate Organogenesis > From a Tubular Primordium: Branched Birth Defects > Organ Anomalies.

AB - Kidneys are bilateral organs required to maintain homeostasis in the body through the regulation of fluid composition and the excretion of metabolic waste products. The initial steps in organ development are characterized by cellular interactions which regulate both the position and number of kidneys formed. Once established, further development is driven by orchestrated interactions between progenitor cell populations which serve to establish both nephrons—the functional unit of the organ which filters the blood—and the complex ramified collecting duct system which transports urine to the bladder. The delicate balance involved in these processes is reflected in the emerging family of genetic or environmental factors which, when perturbed, give rise to defects in organ development or function later in life. This article is categorized under: Vertebrate Organogenesis > From a Tubular Primordium: Branched Birth Defects > Organ Anomalies.

KW - branching morphogenesis

KW - congenital abnormalities of the kidneys and urinary tract

KW - kidney development

UR - http://www.scopus.com/inward/record.url?scp=85058965084&partnerID=8YFLogxK

U2 - 10.1002/wdev.338

DO - 10.1002/wdev.338

M3 - Article

VL - 8

JO - Wiley Interdisciplinary Reviews: Developmental Biology

JF - Wiley Interdisciplinary Reviews: Developmental Biology

SN - 1759-7684

IS - 2

M1 - e338

ER -