Cell therapy: a novel treatment approach for bronchopulmonary dysplasia

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Bronchopulmonary dysplasia (BPD) is a major cause of substantial lifelong morbidity in preterm infants. Despite a better understanding of the pathophysiology of BPD and significant research effort into its management, there remains today no effective treatment. Cell-based therapy is a novel approach that offers much promise in the prevention and treatment of BPD. Recent research supports a therapeutic role for cell transplantation in the management of a variety of acute and chronic adult and childhood lung diseases, with potential of such therapy to reduce inflammation and prevent acute lung injury. However, considerable uncertainties remain regarding cell therapies before they can be established as safe and effective clinical treatments for BPD. This review summarizes the current literature investigating cell therapies in lung disease, with particular focus on the various types of cells available and their specific properties in the context of a future therapy for BPD.
Original languageEnglish
Pages (from-to)727 - 737
Number of pages11
JournalPediatrics
Volume130
Issue number4
DOIs
Publication statusPublished - 2012

Cite this

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title = "Cell therapy: a novel treatment approach for bronchopulmonary dysplasia",
abstract = "Bronchopulmonary dysplasia (BPD) is a major cause of substantial lifelong morbidity in preterm infants. Despite a better understanding of the pathophysiology of BPD and significant research effort into its management, there remains today no effective treatment. Cell-based therapy is a novel approach that offers much promise in the prevention and treatment of BPD. Recent research supports a therapeutic role for cell transplantation in the management of a variety of acute and chronic adult and childhood lung diseases, with potential of such therapy to reduce inflammation and prevent acute lung injury. However, considerable uncertainties remain regarding cell therapies before they can be established as safe and effective clinical treatments for BPD. This review summarizes the current literature investigating cell therapies in lung disease, with particular focus on the various types of cells available and their specific properties in the context of a future therapy for BPD.",
author = "Patricia Vosdoganes and Lim, {Rebecca Seok Wai} and Moss, {Timothy James Murugesan} and Wallace, {Euan Morrison}",
year = "2012",
doi = "10.1542/peds.2011-2576",
language = "English",
volume = "130",
pages = "727 -- 737",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
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}

Cell therapy: a novel treatment approach for bronchopulmonary dysplasia. / Vosdoganes, Patricia; Lim, Rebecca Seok Wai; Moss, Timothy James Murugesan; Wallace, Euan Morrison.

In: Pediatrics, Vol. 130, No. 4, 2012, p. 727 - 737.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Cell therapy: a novel treatment approach for bronchopulmonary dysplasia

AU - Vosdoganes, Patricia

AU - Lim, Rebecca Seok Wai

AU - Moss, Timothy James Murugesan

AU - Wallace, Euan Morrison

PY - 2012

Y1 - 2012

N2 - Bronchopulmonary dysplasia (BPD) is a major cause of substantial lifelong morbidity in preterm infants. Despite a better understanding of the pathophysiology of BPD and significant research effort into its management, there remains today no effective treatment. Cell-based therapy is a novel approach that offers much promise in the prevention and treatment of BPD. Recent research supports a therapeutic role for cell transplantation in the management of a variety of acute and chronic adult and childhood lung diseases, with potential of such therapy to reduce inflammation and prevent acute lung injury. However, considerable uncertainties remain regarding cell therapies before they can be established as safe and effective clinical treatments for BPD. This review summarizes the current literature investigating cell therapies in lung disease, with particular focus on the various types of cells available and their specific properties in the context of a future therapy for BPD.

AB - Bronchopulmonary dysplasia (BPD) is a major cause of substantial lifelong morbidity in preterm infants. Despite a better understanding of the pathophysiology of BPD and significant research effort into its management, there remains today no effective treatment. Cell-based therapy is a novel approach that offers much promise in the prevention and treatment of BPD. Recent research supports a therapeutic role for cell transplantation in the management of a variety of acute and chronic adult and childhood lung diseases, with potential of such therapy to reduce inflammation and prevent acute lung injury. However, considerable uncertainties remain regarding cell therapies before they can be established as safe and effective clinical treatments for BPD. This review summarizes the current literature investigating cell therapies in lung disease, with particular focus on the various types of cells available and their specific properties in the context of a future therapy for BPD.

UR - http://www.ncbi.nlm.nih.gov/pubmed/22945412

U2 - 10.1542/peds.2011-2576

DO - 10.1542/peds.2011-2576

M3 - Article

VL - 130

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EP - 737

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 4

ER -