Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 727 - 737 |
| Number of pages | 11 |
| Journal | Pediatrics |
| Volume | 130 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2012 |
Cite this
}
Cell therapy: a novel treatment approach for bronchopulmonary dysplasia. / Vosdoganes, Patricia; Lim, Rebecca Seok Wai; Moss, Timothy James Murugesan; Wallace, Euan Morrison.
In: Pediatrics, Vol. 130, No. 4, 2012, p. 727 - 737.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Cell therapy: a novel treatment approach for bronchopulmonary dysplasia
AU - Vosdoganes, Patricia
AU - Lim, Rebecca Seok Wai
AU - Moss, Timothy James Murugesan
AU - Wallace, Euan Morrison
PY - 2012
Y1 - 2012
N2 - Bronchopulmonary dysplasia (BPD) is a major cause of substantial lifelong morbidity in preterm infants. Despite a better understanding of the pathophysiology of BPD and significant research effort into its management, there remains today no effective treatment. Cell-based therapy is a novel approach that offers much promise in the prevention and treatment of BPD. Recent research supports a therapeutic role for cell transplantation in the management of a variety of acute and chronic adult and childhood lung diseases, with potential of such therapy to reduce inflammation and prevent acute lung injury. However, considerable uncertainties remain regarding cell therapies before they can be established as safe and effective clinical treatments for BPD. This review summarizes the current literature investigating cell therapies in lung disease, with particular focus on the various types of cells available and their specific properties in the context of a future therapy for BPD.
AB - Bronchopulmonary dysplasia (BPD) is a major cause of substantial lifelong morbidity in preterm infants. Despite a better understanding of the pathophysiology of BPD and significant research effort into its management, there remains today no effective treatment. Cell-based therapy is a novel approach that offers much promise in the prevention and treatment of BPD. Recent research supports a therapeutic role for cell transplantation in the management of a variety of acute and chronic adult and childhood lung diseases, with potential of such therapy to reduce inflammation and prevent acute lung injury. However, considerable uncertainties remain regarding cell therapies before they can be established as safe and effective clinical treatments for BPD. This review summarizes the current literature investigating cell therapies in lung disease, with particular focus on the various types of cells available and their specific properties in the context of a future therapy for BPD.
UR - http://www.ncbi.nlm.nih.gov/pubmed/22945412
U2 - 10.1542/peds.2011-2576
DO - 10.1542/peds.2011-2576
M3 - Article
VL - 130
SP - 727
EP - 737
JO - Pediatrics
JF - Pediatrics
SN - 0031-4005
IS - 4
ER -