Cell-specific ionic models of cardiac pacemaker activity

S Dokos, SL Cloherty, NH Lovell, A Zaza

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review

Abstract

We have developed a generic ionic model of single-cell rabbit sinoatrial node (SAN) electrical activity, employing Markov-state kinetics for membrane ionic currents. By suitable choice of parameters, the model is able to accurately reproduce a wide range of action potential waveforms recorded from individual SAN cells in the laboratory. Advantages of this approach include the ability to quantitatively investigate the contribution of ion currents underlying pacemaker and action potential activity from any given SAN myocyte recording.
Original languageEnglish
Title of host publicationProceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-4: Building New Bridges at The Frontiers of Engineering and Medicine
Pages17-18
Number of pages2
Volume23
Publication statusPublished - 2001
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2001: Building new bridges at the frontiers of Engineering and Medicine - Istanbul, Turkey
Duration: 24 Oct 200127 Oct 2001
Conference number: 23rd

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2001
Abbreviated titleEMBC 2001
CountryTurkey
CityIstanbul
Period24/10/0127/10/01

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