Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate

Annelie Carlsbecker, Ji-Young Lee, Christina Roberts, Jan Dettmer, Satu Lehesranta, Jing Zhou, Ove Lindgren, Miguel Moreno-Risueno, Anne Vaten, Siripong Thiramadee, Ana Campilho, Jose Sebastian, John Bowman, Yka Helariutta, Philip Benfey

Research output: Contribution to journalArticleResearchpeer-review

529 Citations (Scopus)

Abstract

A key question in developmental biology is how cells exchange positional information for proper patterning during organ development. In plant roots the radial tissue organization is highly conserved with a central vascular cylinder in which two water conducting cell types, protoxylem and metaxylem, are patterned centripetally. We show that this patterning occurs through crosstalk between the vascular cylinder and the surrounding endodermis mediated by cell-to-cell movement of a transcription factor in one direction and microRNAs in the other.
Original languageEnglish
Pages (from-to)316 - 321
Number of pages6
JournalNature
Volume465
Issue number7296
DOIs
Publication statusPublished - 2010

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