Cell migration from baby to mother

Gavin S Dawe, Xiao Wei Tan, Zhi-Cheng Xiao

Research output: Contribution to journalArticleOther

50 Citations (Scopus)

Abstract

Fetal cells migrate into the mother during pregnancy. Fetomaternal transfer probably occurs in all pregnancies and in humans the fetal cells can persist for decades. Microchimeric fetal cells are found in various maternal tissues and organs including blood, bone marrow, skin and liver. In mice, fetal cells have also been found in the brain. The fetal cells also appear to target sites of injury. Fetomaternal microchimerism may have important implications for the immune status of women, influencing autoimmunity and tolerance to transplants. Further understanding of the ability of fetal cells to cross both the placental and blood-brain barriers, to migrate into diverse tissues, and to differentiate into multiple cell types may also advance strategies for intravenous transplantation of stem cells for cytotherapeutic repair. Here we discuss hypotheses for how fetal cells cross the placental and blood-brain barriers and the persistence and distribution of fetal cells in the mother.
Original languageEnglish
Pages (from-to)19 - 27
Number of pages9
JournalCell Adhesion and Migration
Volume1
Issue number1
Publication statusPublished - 2007
Externally publishedYes

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