@article{4545fd029c1f42bf94b7d10c6ffc1729,
title = "Cell-in-Cell Structures in the Liver: A Tale of Four E{\textquoteright}s",
abstract = "The liver is our largest internal organ and it plays major roles in drug detoxification and immunity, where the ingestion of extracellular material through phagocytosis is a critical pathway. Phagocytosis is the deliberate endocytosis of large particles, microbes, dead cells or cell debris and can lead to cell-in-cell structures. Various types of cell endocytosis have been recently described for hepatic epithelia (hepatocytes), which are non-professional phagocytes. Given that up to 80\% of the liver comprises hepatocytes, the biological impact of cell-in-cell structures in the liver can have profound effects in liver regeneration, inflammation and cancer. This review brings together the latest reports on four types of endocytosis in the liver -efferocytosis, entosis, emperipolesis and enclysis, with a focus on hepatocyte biology.",
keywords = "cancer, cell-in-cell, efferocytosis, emperipolesis, enclysis, entosis, liver, regeneration",
author = "Davies, \{Scott P.\} and Terry, \{Lauren V.\} and Wilkinson, \{Alex L.\} and Zania Stamataki",
note = "Funding Information: SD was funded by an NC3R trainee fellowship. LT was funded by an MRC iCASE fellowship, and AW was funded by a Wellcome Trust Ph.D. studentship in Mechanisms of Inflammatory Diseases. This work was initiated thanks to support from a small seed award by Wellcome Trust Institutional Support Fund to ZS, who has subsequently received funding from the Medical Research Foundation (MRC), Wellcome Trust, GMG, The Birmingham Children{\textquoteright}s Hospital Research Foundation, and a Royal Society Dorothy Hodgkin Fellowship. This manuscript presents independent research supported by the NIHR Birmingham Biomedical Research Centre at the University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Davies, Terry, Wilkinson and Stamataki.",
year = "2020",
month = may,
day = "13",
doi = "10.3389/fimmu.2020.00650",
language = "English",
volume = "11",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media SA",
}
