Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 170 - 179 |
| Number of pages | 10 |
| Journal | Diabetologia |
| Volume | 53 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 |
Cite this
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Cell division autoantigen 1 plays a profibrotic role by modulating downstream signalling of TGF-? in a murine diabetic model of atherosclerosis. / Pham, Yen; Tu, Yugang; Wu, Tieqiao; Allen, Terri J; Calkin, Anna; Watson, Anna M; Li, Jiaze; Jandeleit-Dahm, Karin A; Toh, Ban-Hock; Cao, Zemin M; Cooper, M E; Chai, Zhonglin.
In: Diabetologia, Vol. 53, No. 1, 2010, p. 170 - 179.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Cell division autoantigen 1 plays a profibrotic role by modulating downstream signalling of TGF-? in a murine diabetic model of atherosclerosis
AU - Pham, Yen
AU - Tu, Yugang
AU - Wu, Tieqiao
AU - Allen, Terri J
AU - Calkin, Anna
AU - Watson, Anna M
AU - Li, Jiaze
AU - Jandeleit-Dahm, Karin A
AU - Toh, Ban-Hock
AU - Cao, Zemin M
AU - Cooper, M E
AU - Chai, Zhonglin
PY - 2010
Y1 - 2010
N2 - Excess accumulation of vascular extracellular matrix (ECM) is an important pathological process in cardiovascular diseases including diabetes-associated atherosclerosis. We explored how a recently identified molecule, cell division autoantigen 1 (CDA1), influences the profibrotic TGF-beta pathway leading to vascular ECM accumulation. Expression levels of genes encoding for CDA1, TGF-beta and connective tissue growth factor (CTGF) were examined in aorta from Apoe(-/-) mice with or without diabetes. We used retroviral and adenoviral constructs to knockdown or overexpress Tspyl2, the gene encoding CDA1, in mouse vascular smooth muscle cells (VSMCs) with or without TGF-beta treatment in order to demonstrate the role of CDA1 in TGF-beta signalling.
AB - Excess accumulation of vascular extracellular matrix (ECM) is an important pathological process in cardiovascular diseases including diabetes-associated atherosclerosis. We explored how a recently identified molecule, cell division autoantigen 1 (CDA1), influences the profibrotic TGF-beta pathway leading to vascular ECM accumulation. Expression levels of genes encoding for CDA1, TGF-beta and connective tissue growth factor (CTGF) were examined in aorta from Apoe(-/-) mice with or without diabetes. We used retroviral and adenoviral constructs to knockdown or overexpress Tspyl2, the gene encoding CDA1, in mouse vascular smooth muscle cells (VSMCs) with or without TGF-beta treatment in order to demonstrate the role of CDA1 in TGF-beta signalling.
U2 - 10.1007/s00125-009-1555-9
DO - 10.1007/s00125-009-1555-9
M3 - Article
VL - 53
SP - 170
EP - 179
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 1
ER -