Cell death in the hematopoietic system

Emma C Josefsson, Benjamin T. Kile

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

3 Citations (Scopus)

Abstract

The mammalian hematopoietic system is prodigious: billions of blood cells are generated every day to maintain the supply of oxygen to the tissues, repair damaged vasculature, and resist infection. It is becoming increasingly clear that the intrinsic apoptosis pathway, under the control of the Bcl-2 family of proteins, plays many essential roles in the development and function of hematopoietic cells of most, if not all, of the various lineages. It promotes survival, regulates key aspects of maturation and function, and ultimately triggers the timely demise of functionally expended cells. In this chapter, we review the role of the intrinsic pathway in mediating the life and death of the non-lymphoid hematopoietic lineages.

Original languageEnglish
Title of host publicationEssentials of Apoptosis: A Guide for Basic and Clinical Research
PublisherHumana Press
Pages443-459
Number of pages17
ISBN (Electronic)9781603273817
ISBN (Print)9781603273800
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • Apoptosis
  • Bcl-2 family proteins
  • Erythrocytes
  • Hematopoietic stem cells
  • Macrophages
  • Megakaryocytes
  • Neutrophils
  • Platelets
  • Progenitor cells

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