Celecoxib, but not rofecoxib or naproxen, attenuates cardiac hypertrophy and fibrosis induced in vitro by angiotensin and aldosterone

Bing Wang, Micka Bertucci, Jian Ma, Anastasia Adrahtas, Raymond Cheung, Henry Krum

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13 Citations (Scopus)

Abstract

Given the important role of the renini??angiotensini??aldosterone system (RAAS) in cardiac remodelling, we sought to determine the effect of COX-2 inhibitors and non-specific (NS-) NSAIDs on RAAS-induced cardiac hypertrophy and fibrosis in neonatal rat cardiac myocytes (NCM) and fibroblasts (NCF) isolated from 1i??2-day-old Sprague-Dawley rat pups.
Original languageEnglish
Pages (from-to)912 - 918
Number of pages7
JournalClinical and Experimental Pharmacology and Physiology
Volume37
Issue number9
DOIs
Publication statusPublished - 2010

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