TY - JOUR
T1 - Celastrol
T2 - A Potential Natural Lead Molecule for New Drug Design, Development and Therapy for Memory Impairment
AU - Amir Yusri, Muhamad Azrul
AU - Sekar, Mahendran
AU - Wong, Ling Shing
AU - Gan, Siew Hua
AU - Ravi, Subban
AU - Subramaniyan, Vetriselvan
AU - Mat Rani, Nur Najihah Izzati
AU - Chidambaram, Kumarappan
AU - Begum, M. Yasmin
AU - Ramar, Mohankumar
AU - Safi, Sher Zaman
AU - Selvaraj, Siddharthan
AU - Wu, Yuan Seng
AU - Revathy, Palanisamy
AU - Fuloria, Shivkanya
AU - Fuloria, Neeraj Kumar
AU - Lum, Pei Teng
AU - Djearamane, Sinouvassane
N1 - Publisher Copyright:
© 2023 Amir Yusri et al.
PY - 2023/4
Y1 - 2023/4
N2 - Celastrol is a naturally occurring chemical isolated from Tripterygium wilfordii Hook. f., root extracts widely known for their neuroprotective properties. In this review, we focus on the efficacy of celastrol in mitigating memory impairment (MI) in both in vivo and in vitro models. Scopus, PubMed and Web of Science databases were utilised to locate pertinent literatures that explore the effects of celastrol in the brain, including its pharmacokinetics, bioavailability, behavioral effects and some of the putative mechanisms of action on memory in many MI models. To date, preclinical studies strongly suggest that celastrol is highly effective in enhancing the cognitive performance of MI animal models, particularly in the memory domain, including spatial, recognition, retention and reference memories, via reduction in oxidative stress and attenuation of neuro-inflammation, among others. This review also emphasised the challenges and potential associated enhancement of medication delivery for MI treatment. Additionally, the potential structural alterations and derivatives of celastrol in enhancing its physicochemical and drug-likeness qualities are examined. The current review demonstrated that celastrol can improve cognitive performance and mitigate MI in several preclinical investigations, highlighting its potential as a natural lead molecule for the design and development of a novel neuroprotective medication.
AB - Celastrol is a naturally occurring chemical isolated from Tripterygium wilfordii Hook. f., root extracts widely known for their neuroprotective properties. In this review, we focus on the efficacy of celastrol in mitigating memory impairment (MI) in both in vivo and in vitro models. Scopus, PubMed and Web of Science databases were utilised to locate pertinent literatures that explore the effects of celastrol in the brain, including its pharmacokinetics, bioavailability, behavioral effects and some of the putative mechanisms of action on memory in many MI models. To date, preclinical studies strongly suggest that celastrol is highly effective in enhancing the cognitive performance of MI animal models, particularly in the memory domain, including spatial, recognition, retention and reference memories, via reduction in oxidative stress and attenuation of neuro-inflammation, among others. This review also emphasised the challenges and potential associated enhancement of medication delivery for MI treatment. Additionally, the potential structural alterations and derivatives of celastrol in enhancing its physicochemical and drug-likeness qualities are examined. The current review demonstrated that celastrol can improve cognitive performance and mitigate MI in several preclinical investigations, highlighting its potential as a natural lead molecule for the design and development of a novel neuroprotective medication.
KW - celastrol
KW - drug discovery
KW - memory impairment
KW - natural products
KW - neuroprotection
UR - https://www.scopus.com/pages/publications/85152632671
U2 - 10.2147/DDDT.S389977
DO - 10.2147/DDDT.S389977
M3 - Review Article
C2 - 37064431
AN - SCOPUS:85152632671
SN - 1177-8881
VL - 17
SP - 1079
EP - 1096
JO - Drug Design, Development and Therapy
JF - Drug Design, Development and Therapy
ER -