CD8α+ mouse spleen dendritic cells do not originate from the CD8α- dendritic cell subset

Shalin Naik, David Vremec, Li Wu, Meredith O'Keeffe, Ken Shortman

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)


Although previous studies had indicated that the CD8α- and CD8α+ subtypes of murine dendritic cells (DCs) differ in immediate origin, a recent study found that intravenous transfer of CD8α- DCs led to CD8α+ DCs in the spleen several days later, suggesting a direct precursor-product relationship. We have repeated these experiments with a balance sheet approach. We find that though a few CD8α+ DCs can be generated in such experiments, this is a rare event and could be the result of a contaminant precursor. Most of the immediate precursors of CD8α+ DCs are cells that lack the phenotype of a recognizable DC. CD8α- DCs and CD8α+ DCs are not precursor-product related, though these sublineages may be connected further upstream.

Original languageEnglish
Pages (from-to)601-604
Number of pages4
Issue number2
Publication statusPublished - 15 Jul 2003
Externally publishedYes

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