CD4+ Th1 cells are effectors in lupus nephritis--but what are their targets?

Research output: Contribution to journalLetterOther

3 Citations (Scopus)

Abstract

Lupus nephritis involves both humoral and cellular effectors. Okamoto and colleagues isolated renal CD4+ cells from lupus-prone mice, selecting cells expressing T-cell receptors on the basis of their activity. After transfecting CD4+ cells with the relevant T-cell receptors, they transferred them into mice and induced more severe glomerulonephritis. This study supports a direct role for Th1 cells in lupus nephritis, although their antigenic specificity remains uncertain, as they did not recognize nucleosomes.
Original languageEnglish
Pages (from-to)947 - 949
Number of pages3
JournalKidney International
Volume82
Issue number9
DOIs
Publication statusPublished - 2012

Cite this

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title = "CD4+ Th1 cells are effectors in lupus nephritis--but what are their targets?",
abstract = "Lupus nephritis involves both humoral and cellular effectors. Okamoto and colleagues isolated renal CD4+ cells from lupus-prone mice, selecting cells expressing T-cell receptors on the basis of their activity. After transfecting CD4+ cells with the relevant T-cell receptors, they transferred them into mice and induced more severe glomerulonephritis. This study supports a direct role for Th1 cells in lupus nephritis, although their antigenic specificity remains uncertain, as they did not recognize nucleosomes.",
author = "Joshua Ooi and Kitching, {Arthur Richard}",
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language = "English",
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journal = "Kidney International",
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number = "9",

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CD4+ Th1 cells are effectors in lupus nephritis--but what are their targets? / Ooi, Joshua; Kitching, Arthur Richard.

In: Kidney International, Vol. 82, No. 9, 2012, p. 947 - 949.

Research output: Contribution to journalLetterOther

TY - JOUR

T1 - CD4+ Th1 cells are effectors in lupus nephritis--but what are their targets?

AU - Ooi, Joshua

AU - Kitching, Arthur Richard

PY - 2012

Y1 - 2012

N2 - Lupus nephritis involves both humoral and cellular effectors. Okamoto and colleagues isolated renal CD4+ cells from lupus-prone mice, selecting cells expressing T-cell receptors on the basis of their activity. After transfecting CD4+ cells with the relevant T-cell receptors, they transferred them into mice and induced more severe glomerulonephritis. This study supports a direct role for Th1 cells in lupus nephritis, although their antigenic specificity remains uncertain, as they did not recognize nucleosomes.

AB - Lupus nephritis involves both humoral and cellular effectors. Okamoto and colleagues isolated renal CD4+ cells from lupus-prone mice, selecting cells expressing T-cell receptors on the basis of their activity. After transfecting CD4+ cells with the relevant T-cell receptors, they transferred them into mice and induced more severe glomerulonephritis. This study supports a direct role for Th1 cells in lupus nephritis, although their antigenic specificity remains uncertain, as they did not recognize nucleosomes.

UR - http://www.ncbi.nlm.nih.gov/pubmed/23064187

U2 - 10.1038/ki.2012.254

DO - 10.1038/ki.2012.254

M3 - Letter

VL - 82

SP - 947

EP - 949

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 9

ER -