CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells

Sonia Fernandez, Sara Tanaskovic, Karla Helbig, Reena Rajasuriar, Marit Kramski, John M Murray, Michael R Beard, Anthony Wayne Purcell, Sharon Ruth Lewin, Patricia Price, Martyn French

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66 Citations (Scopus)

Abstract

Most patients with human immunodeficiency virus (HIV) who remain CD41 T-cell deficient on antiretroviral therapy (ART) exhibit marked immune activation. As CD41 T-cell activation may be mediated by microbial translocation or interferon-alpha (IFN-a), we examined these factors in HIV patients with good or poor CD41 T-cell recovery on long-term ART. Messenger RNA levels for 3 interferon-stimulated genes were increased in CD41 T cells of patients with poor CD41 T-cell recovery, whereas levels in patients with good recovery did not differ from those in healthy controls
Original languageEnglish
Pages (from-to)1 - 9
Number of pages9
JournalJournal of Infectious Diseases
Volume204
Issue number12
DOIs
Publication statusPublished - 2011

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