Abstract
Most patients with human immunodeficiency virus (HIV) who remain CD41 T-cell deficient on antiretroviral
therapy (ART) exhibit marked immune activation. As CD41 T-cell activation may be mediated by microbial
translocation or interferon-alpha (IFN-a), we examined these factors in HIV patients with good or poor CD41
T-cell recovery on long-term ART. Messenger RNA levels for 3 interferon-stimulated genes were increased in
CD41 T cells of patients with poor CD41 T-cell recovery, whereas levels in patients with good recovery did not
differ from those in healthy controls
Original language | English |
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Pages (from-to) | 1 - 9 |
Number of pages | 9 |
Journal | Journal of Infectious Diseases |
Volume | 204 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2011 |