CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells

Sonia Fernandez, Sara Tanaskovic, Karla Helbig, Reena Rajasuriar, Marit Kramski, John M Murray, Michael R Beard, Anthony Wayne Purcell, Sharon Ruth Lewin, Patricia Price, Martyn French

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

Most patients with human immunodeficiency virus (HIV) who remain CD41 T-cell deficient on antiretroviral therapy (ART) exhibit marked immune activation. As CD41 T-cell activation may be mediated by microbial translocation or interferon-alpha (IFN-a), we examined these factors in HIV patients with good or poor CD41 T-cell recovery on long-term ART. Messenger RNA levels for 3 interferon-stimulated genes were increased in CD41 T cells of patients with poor CD41 T-cell recovery, whereas levels in patients with good recovery did not differ from those in healthy controls
Original languageEnglish
Pages (from-to)1 - 9
Number of pages9
JournalJournal of Infectious Diseases
Volume204
Issue number12
DOIs
Publication statusPublished - 2011

Cite this

Fernandez, Sonia ; Tanaskovic, Sara ; Helbig, Karla ; Rajasuriar, Reena ; Kramski, Marit ; Murray, John M ; Beard, Michael R ; Purcell, Anthony Wayne ; Lewin, Sharon Ruth ; Price, Patricia ; French, Martyn. / CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells. In: Journal of Infectious Diseases. 2011 ; Vol. 204, No. 12. pp. 1 - 9.
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title = "CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells",
abstract = "Most patients with human immunodeficiency virus (HIV) who remain CD41 T-cell deficient on antiretroviral therapy (ART) exhibit marked immune activation. As CD41 T-cell activation may be mediated by microbial translocation or interferon-alpha (IFN-a), we examined these factors in HIV patients with good or poor CD41 T-cell recovery on long-term ART. Messenger RNA levels for 3 interferon-stimulated genes were increased in CD41 T cells of patients with poor CD41 T-cell recovery, whereas levels in patients with good recovery did not differ from those in healthy controls",
author = "Sonia Fernandez and Sara Tanaskovic and Karla Helbig and Reena Rajasuriar and Marit Kramski and Murray, {John M} and Beard, {Michael R} and Purcell, {Anthony Wayne} and Lewin, {Sharon Ruth} and Patricia Price and Martyn French",
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Fernandez, S, Tanaskovic, S, Helbig, K, Rajasuriar, R, Kramski, M, Murray, JM, Beard, MR, Purcell, AW, Lewin, SR, Price, P & French, M 2011, 'CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells', Journal of Infectious Diseases, vol. 204, no. 12, pp. 1 - 9. https://doi.org/10.1093/infdis/jir659

CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells. / Fernandez, Sonia; Tanaskovic, Sara; Helbig, Karla; Rajasuriar, Reena; Kramski, Marit; Murray, John M; Beard, Michael R; Purcell, Anthony Wayne; Lewin, Sharon Ruth; Price, Patricia; French, Martyn.

In: Journal of Infectious Diseases, Vol. 204, No. 12, 2011, p. 1 - 9.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells

AU - Fernandez, Sonia

AU - Tanaskovic, Sara

AU - Helbig, Karla

AU - Rajasuriar, Reena

AU - Kramski, Marit

AU - Murray, John M

AU - Beard, Michael R

AU - Purcell, Anthony Wayne

AU - Lewin, Sharon Ruth

AU - Price, Patricia

AU - French, Martyn

PY - 2011

Y1 - 2011

N2 - Most patients with human immunodeficiency virus (HIV) who remain CD41 T-cell deficient on antiretroviral therapy (ART) exhibit marked immune activation. As CD41 T-cell activation may be mediated by microbial translocation or interferon-alpha (IFN-a), we examined these factors in HIV patients with good or poor CD41 T-cell recovery on long-term ART. Messenger RNA levels for 3 interferon-stimulated genes were increased in CD41 T cells of patients with poor CD41 T-cell recovery, whereas levels in patients with good recovery did not differ from those in healthy controls

AB - Most patients with human immunodeficiency virus (HIV) who remain CD41 T-cell deficient on antiretroviral therapy (ART) exhibit marked immune activation. As CD41 T-cell activation may be mediated by microbial translocation or interferon-alpha (IFN-a), we examined these factors in HIV patients with good or poor CD41 T-cell recovery on long-term ART. Messenger RNA levels for 3 interferon-stimulated genes were increased in CD41 T cells of patients with poor CD41 T-cell recovery, whereas levels in patients with good recovery did not differ from those in healthy controls

UR - http://jid.oxfordjournals.org/content/early/2011/10/17/infdis.jir659.full.pdf+html

U2 - 10.1093/infdis/jir659

DO - 10.1093/infdis/jir659

M3 - Article

VL - 204

SP - 1

EP - 9

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 12

ER -

Fernandez S, Tanaskovic S, Helbig K, Rajasuriar R, Kramski M, Murray JM et al. CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells. Journal of Infectious Diseases. 2011;204(12):1 - 9. https://doi.org/10.1093/infdis/jir659

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