TY - JOUR
T1 - CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells
AU - Schofield, Louis
AU - McConville, Malcolm J.
AU - Hansen, Diana
AU - Campbell, A. Stewart
AU - Fraser-Reid, Bert
AU - Grusby, Michael J.
AU - Tachado, Souvenir D.
PY - 1999/1/8
Y1 - 1999/1/8
N2 - Immunoglobulin G (IgG) responses require major histocompatibility complex (MHC)-restricted recognition of peptide fragments by conventional CD4+ helper T cells. Immunoglobulin G responses to glycosylphosphatidylinositol (GPI)-anchored protein antigens, however, were found to be regulated in part through CD1d-restricted recognition of the GPI moiety by thymus-dependent, interleukin-4-producing CD4+, natural killer cell antigen 1.1 [(NK1.1)+] helper T cells. The CD1-NKT cell pathway regulated immunoglobulin G responses to the GPI-anchored surface antigens of Plasmodium and Trypanosoma and may be a general mechanism for rapid, MHC- unrestricted antibody responses to diverse pathogens.
AB - Immunoglobulin G (IgG) responses require major histocompatibility complex (MHC)-restricted recognition of peptide fragments by conventional CD4+ helper T cells. Immunoglobulin G responses to glycosylphosphatidylinositol (GPI)-anchored protein antigens, however, were found to be regulated in part through CD1d-restricted recognition of the GPI moiety by thymus-dependent, interleukin-4-producing CD4+, natural killer cell antigen 1.1 [(NK1.1)+] helper T cells. The CD1-NKT cell pathway regulated immunoglobulin G responses to the GPI-anchored surface antigens of Plasmodium and Trypanosoma and may be a general mechanism for rapid, MHC- unrestricted antibody responses to diverse pathogens.
UR - https://www.scopus.com/pages/publications/0033534391
U2 - 10.1126/science.283.5399.225
DO - 10.1126/science.283.5399.225
M3 - Article
C2 - 9880256
AN - SCOPUS:0033534391
SN - 0036-8075
VL - 283
SP - 225
EP - 229
JO - Science
JF - Science
IS - 5399
ER -