CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells

Louis Schofield, Malcolm J. McConville, Diana Hansen, A. Stewart Campbell, Bert Fraser-Reid, Michael J. Grusby, Souvenir D. Tachado

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6 Citations (Scopus)

Abstract

Immunoglobulin G (IgG) responses require major histocompatibility complex (MHC)-restricted recognition of peptide fragments by conventional CD4+ helper T cells. Immunoglobulin G responses to glycosylphosphatidylinositol (GPI)-anchored protein antigens, however, were found to be regulated in part through CD1d-restricted recognition of the GPI moiety by thymus-dependent, interleukin-4-producing CD4+, natural killer cell antigen 1.1 [(NK1.1)+] helper T cells. The CD1-NKT cell pathway regulated immunoglobulin G responses to the GPI-anchored surface antigens of Plasmodium and Trypanosoma and may be a general mechanism for rapid, MHC- unrestricted antibody responses to diverse pathogens.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalScience
Volume283
Issue number5399
DOIs
Publication statusPublished - 8 Jan 1999
Externally publishedYes

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