Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1137-1145 |
| Number of pages | 9 |
| Journal | Nature Immunology |
| Volume | 14 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2013 |
Cite this
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CD1d-lipid antigen recognition by the γδ TCR. / Uldrich, Adam P; Le Nours, Jerome; Pellicci, Daniel G; Gherardin, Nicholas A; McPherson, Kristy G; Lim, Ricky T; Patel, Onisha; Beddoe, Travis Clarke; Gras, Stephanie; Rossjohn, Jamie; Godfrey, Dale I.
In: Nature Immunology, Vol. 14, No. 11, 2013, p. 1137-1145.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - CD1d-lipid antigen recognition by the γδ TCR
AU - Uldrich, Adam P
AU - Le Nours, Jerome
AU - Pellicci, Daniel G
AU - Gherardin, Nicholas A
AU - McPherson, Kristy G
AU - Lim, Ricky T
AU - Patel, Onisha
AU - Beddoe, Travis Clarke
AU - Gras, Stephanie
AU - Rossjohn, Jamie
AU - Godfrey, Dale I
PY - 2013
Y1 - 2013
N2 - The T cell repertoire comprises alphabeta and gammadelta T cell lineages. Although it is established how alphabeta T cell antigen receptors (TCRs) interact with antigen presented by antigen-presenting molecules, this is unknown for gammadelta TCRs. We describe a population of human Vdelta1(+) gammadelta T cells that exhibit autoreactivity to CD1d and provide a molecular basis for how a gammadelta TCR binds CD1d-alpha-galactosylceramide (alpha-GalCer). The gammadelta TCR docked orthogonally, over the A pocket of CD1d, in which the Vdelta1-chain, and in particular the germ line-encoded CDR1delta loop, dominated interactions with CD1d. The TCR gamma-chain sat peripherally to the interface, with the CDR3gamma loop representing the principal determinant for alpha-GalCer specificity. Accordingly, we provide insight into how a gammadelta TCR binds specifically to a lipid-loaded antigen-presenting molecule.
AB - The T cell repertoire comprises alphabeta and gammadelta T cell lineages. Although it is established how alphabeta T cell antigen receptors (TCRs) interact with antigen presented by antigen-presenting molecules, this is unknown for gammadelta TCRs. We describe a population of human Vdelta1(+) gammadelta T cells that exhibit autoreactivity to CD1d and provide a molecular basis for how a gammadelta TCR binds CD1d-alpha-galactosylceramide (alpha-GalCer). The gammadelta TCR docked orthogonally, over the A pocket of CD1d, in which the Vdelta1-chain, and in particular the germ line-encoded CDR1delta loop, dominated interactions with CD1d. The TCR gamma-chain sat peripherally to the interface, with the CDR3gamma loop representing the principal determinant for alpha-GalCer specificity. Accordingly, we provide insight into how a gammadelta TCR binds specifically to a lipid-loaded antigen-presenting molecule.
UR - http://www.nature.com/ni/journal/v14/n11/pdf/ni.2713.pdf
U2 - 10.1038/ni.2713
DO - 10.1038/ni.2713
M3 - Article
VL - 14
SP - 1137
EP - 1145
JO - Nature Immunology
JF - Nature Immunology
SN - 1529-2908
IS - 11
ER -