CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse

Florian Wiede, Phillip Fromm, Iain Comerford, Ervin Kara, Jennifer Bannan, Wolfgang Schuh, Charani Ranasinghe, David M Tarlinton, Thomas Winkler, Shaun R McColl, Heinrich Korner

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17 Citations (Scopus)

Abstract

The CC-chemokine receptor 6 (CCR6) is expressed constitutively at an intermediate level on naive B cells and is upregulated after activation on pregerminal center (GC) B cells. We hypothesized that it could be involved in the events leading to GC reaction and high-affinity antibody production, and therefore investigated the potential role of CCR6 in B-cell differentiation in vivo. After antigenic challenge of CCR6(-/-) mice with the T-cell-dependent antigen nitrophenyl-keyhole limpet hemocyanin (NP-KLH), GC B-cell development was found to be accelerated and the number of GC had increased significantly compared with control mice, but the antibodies produced by CCR6(-/-) B cells were on average of lower affinity. We conclude from these data that the CCR6/CCL20 axis has an important role in regulating the kinetics and efficiency of the GC reaction.
Original languageEnglish
Pages (from-to)335 - 339
Number of pages5
JournalImmunology and Cell Biology
Volume91
Issue number5
DOIs
Publication statusPublished - 2013

Cite this

Wiede, F., Fromm, P., Comerford, I., Kara, E., Bannan, J., Schuh, W., Ranasinghe, C., Tarlinton, D. M., Winkler, T., McColl, S. R., & Korner, H. (2013). CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse. Immunology and Cell Biology, 91(5), 335 - 339. https://doi.org/10.1038/icb.2013.14