CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

Jianglin He, Youzhi Chen, Michael Farzan, Hyeryun Choe, Asa Ohagen, Suzanne Gartner, Jorge Busciglio, Xiaoyu Yang, Wolfgang Hofmann, Walter Newman, Charles R. Mackay, Joseph Sodroski, Dana Gabuzda

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764 Citations (Scopus)

Abstract

Several members of the chemokine receptor family are used together with CD4 for HIV-1 entry into target cells. T cell line-tropic (T-tropic) HIV-1 viruses use the chemokine receptor CXCR4 as a co-receptor, whereas macrophage-tropic (M-tropic) primary viruses use CCR5. Individuals with defective CCR5 alleles exhibit resistance to HIV-1 infection, suggesting that CCR5 has an important role in vivo in HIV-1 replication. A subset of primary viruses can use CCR3 as well as CCR5 as a co-receptor, but the in vivo contribution of CCR3 to HIV-1 infection and pathogenesis is unknown. HIV-1 infects the central nervous system (CNS) and causes the dementia associated with AIDS. Here we report that the major target cells for HIV-1 infection in the CNS, the microglia, express both CCR3 and CCRS. The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV-1 infection of microglia, as did MIP- 1β, which is a CCR5 ligand. Our results suggest that both CCR3 and CCR5 promote efficient infection of the CNS by HIV-1.

Original languageEnglish
Pages (from-to)645-647
Number of pages3
JournalNature
Volume385
Issue number6617
DOIs
Publication statusPublished - 13 Feb 1997
Externally publishedYes

Cite this

He, J., Chen, Y., Farzan, M., Choe, H., Ohagen, A., Gartner, S., ... Gabuzda, D. (1997). CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature, 385(6617), 645-647. https://doi.org/10.1038/385645a0