CCL3L1 dose and HIV-1 susceptibility

Charles R. Mackay

Research output: Contribution to journalShort SurveyOtherpeer-review

10 Citations (Scopus)


Several genetic factors influence HIV-1 susceptibility or AIDS disease progression. A recent study reported on what could be a particularly important genetic determinant for HIV-1 susceptibility and disease progression: copy number of a chemokine gene termed CCL3L1. Individuals with low copy numbers of the gene, relative to their ethnic background, were associated with markedly enhanced HIV-1/AIDS susceptibility. These findings define an important new genetic determinant of HIV-1 susceptibility and further emphasize the importance of the chemokine system, either as elements that inhibit HIV-1 infection or that modulate antiviral immune responses.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalTrends in Molecular Medicine
Issue number5
Publication statusPublished - 1 Jan 2005
Externally publishedYes

Cite this