CCL3L1 dose and HIV-1 susceptibility

Research output: Contribution to journalShort SurveyOtherpeer-review

Abstract

Several genetic factors influence HIV-1 susceptibility or AIDS disease progression. A recent study reported on what could be a particularly important genetic determinant for HIV-1 susceptibility and disease progression: copy number of a chemokine gene termed CCL3L1. Individuals with low copy numbers of the gene, relative to their ethnic background, were associated with markedly enhanced HIV-1/AIDS susceptibility. These findings define an important new genetic determinant of HIV-1 susceptibility and further emphasize the importance of the chemokine system, either as elements that inhibit HIV-1 infection or that modulate antiviral immune responses.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalTrends in Molecular Medicine
Volume11
Issue number5
DOIs
Publication statusPublished - 1 Jan 2005
Externally publishedYes

Cite this

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CCL3L1 dose and HIV-1 susceptibility. / Mackay, Charles R.

In: Trends in Molecular Medicine, Vol. 11, No. 5, 01.01.2005, p. 203-206.

Research output: Contribution to journalShort SurveyOtherpeer-review

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AB - Several genetic factors influence HIV-1 susceptibility or AIDS disease progression. A recent study reported on what could be a particularly important genetic determinant for HIV-1 susceptibility and disease progression: copy number of a chemokine gene termed CCL3L1. Individuals with low copy numbers of the gene, relative to their ethnic background, were associated with markedly enhanced HIV-1/AIDS susceptibility. These findings define an important new genetic determinant of HIV-1 susceptibility and further emphasize the importance of the chemokine system, either as elements that inhibit HIV-1 infection or that modulate antiviral immune responses.

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