CCL2 modulates cytokine production in cultured mouse astrocytes

Bridgette Semple, Tony J Frugier, Maria Cristina Morganti-Kossmann

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The chemokine CCL2 (also known as monocyte chemoattractant protein-1, or MCP-1) is upregulated in patients and rodent models of traumatic brain injury (TBI), contributing to post-traumatic neuroinflammation and degeneration by directing the infiltration of blood-derived macrophages into the injured brain. Our laboratory has previously reported that Ccl2-/- mice show reduced macrophage accumulation and tissue damage, corresponding to improved motor recovery, following experimental TBI. Surprisingly, Ccl2-deficient mice also exhibited delayed but exacerbated secretion of key proinflammatory cytokines in the injured cortex. Thus we sought to further characterise CCL2 s potential ability to modulate immunoactivation of astrocytes in vitro.
Original languageEnglish
Pages (from-to)1 - 11
Number of pages11
JournalJournal of Neuroinflammation
Issue number67
Publication statusPublished - 2010

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