TY - JOUR
T1 - CCL2 modulates cytokine production in cultured mouse astrocytes
AU - Semple, Bridgette
AU - Frugier, Tony J
AU - Morganti-Kossmann, Maria Cristina
PY - 2010
Y1 - 2010
N2 - The chemokine CCL2 (also known as monocyte chemoattractant protein-1, or MCP-1) is upregulated
in patients and rodent models of traumatic brain injury (TBI), contributing to post-traumatic neuroinflammation and
degeneration by directing the infiltration of blood-derived macrophages into the injured brain. Our laboratory has
previously reported that Ccl2-/- mice show reduced macrophage accumulation and tissue damage, corresponding
to improved motor recovery, following experimental TBI. Surprisingly, Ccl2-deficient mice also exhibited delayed
but exacerbated secretion of key proinflammatory cytokines in the injured cortex. Thus we sought to further
characterise CCL2 s potential ability to modulate immunoactivation of astrocytes in vitro.
AB - The chemokine CCL2 (also known as monocyte chemoattractant protein-1, or MCP-1) is upregulated
in patients and rodent models of traumatic brain injury (TBI), contributing to post-traumatic neuroinflammation and
degeneration by directing the infiltration of blood-derived macrophages into the injured brain. Our laboratory has
previously reported that Ccl2-/- mice show reduced macrophage accumulation and tissue damage, corresponding
to improved motor recovery, following experimental TBI. Surprisingly, Ccl2-deficient mice also exhibited delayed
but exacerbated secretion of key proinflammatory cytokines in the injured cortex. Thus we sought to further
characterise CCL2 s potential ability to modulate immunoactivation of astrocytes in vitro.
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964657/pdf/1742-2094-7-67.pdf
U2 - 10.1186/1742-2094-7-67
DO - 10.1186/1742-2094-7-67
M3 - Article
VL - 7
SP - 1
EP - 11
JO - Journal of Neuroinflammation
JF - Journal of Neuroinflammation
SN - 1742-2094
IS - 67
ER -