Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells

Jessica L. Teo; Guillermo A. Gomez; Saroja Weeratunga; Elizabeth M. Davies; Ivar Noordstra; Srikanth Budnar; Hiroko Katsuno-Kambe; Meagan J. McGrath; Suzie Verma; Vanesa Tomatis; Bipul R. Acharya; Lakshmi Balasubramaniam; Rachel M. Templin; Kerrie Ann McMahon; Yoke Seng Lee; Robert J. Ju; Samantha J. Stebhens; Benoit Ladoux; Christina A. Mitchell; Brett M. Collins; Robert G. Parton; Alpha S. Yap

doi:10.1016/j.devcel.2020.05.002

Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells

Jessica L. Teo, Guillermo A. Gomez, Saroja Weeratunga, Elizabeth M. Davies, Ivar Noordstra, Srikanth Budnar, Hiroko Katsuno-Kambe, Meagan J. McGrath, Suzie Verma, Vanesa Tomatis, Bipul R. Acharya, Lakshmi Balasubramaniam, Rachel M. Templin, Kerrie Ann McMahon, Yoke Seng Lee, Robert J. Ju, Samantha J. Stebhens, Benoit Ladoux, Christina A. Mitchell, Brett M. CollinsRobert G. Parton, Alpha S. Yap

Research output: Contribution to journal › Article › Research › peer-review

52 Citations (Scopus)

Abstract

Teo et al. report that caveolae can regulate epithelial contractility by lipid signaling. Caveolin-1 depletion enhanced phosphoinositide-4,5- bisphosphate (PtdIns(4,5)P2) levels to recruit FMNL2, which stabilizes F-actin and increases tension at adherens junctions. Elevated epithelial tension disrupts the elimination of oncogene-expressing cells by apical extrusion.

Original language	English
Pages (from-to)	75-91
Number of pages	18
Journal	Developmental Cell
Volume	54
DOIs	https://doi.org/10.1016/j.devcel.2020.05.002
Publication status	Published - 6 Jul 2020

Keywords

actomyosin
caveolae
epithelial tension
extrusion
phosphoinositides

Access to Document

10.1016/j.devcel.2020.05.002

314141497-oaFinal published version, 4.99 MB

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Teo, J. L., Gomez, G. A., Weeratunga, S., Davies, E. M., Noordstra, I., Budnar, S., Katsuno-Kambe, H., McGrath, M. J., Verma, S., Tomatis, V., Acharya, B. R., Balasubramaniam, L., Templin, R. M., McMahon, K. A., Lee, Y. S., Ju, R. J., Stebhens, S. J., Ladoux, B., Mitchell, C. A., ... Yap, A. S. (2020). Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells. Developmental Cell, 54, 75-91. https://doi.org/10.1016/j.devcel.2020.05.002

@article{a3e52322ba3e4d67ba255e106877c85e,

title = "Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells",

abstract = "Teo et al. report that caveolae can regulate epithelial contractility by lipid signaling. Caveolin-1 depletion enhanced phosphoinositide-4,5- bisphosphate (PtdIns(4,5)P2) levels to recruit FMNL2, which stabilizes F-actin and increases tension at adherens junctions. Elevated epithelial tension disrupts the elimination of oncogene-expressing cells by apical extrusion.",

keywords = "actomyosin, caveolae, epithelial tension, extrusion, phosphoinositides",

author = "Teo, \{Jessica L.\} and Gomez, \{Guillermo A.\} and Saroja Weeratunga and Davies, \{Elizabeth M.\} and Ivar Noordstra and Srikanth Budnar and Hiroko Katsuno-Kambe and McGrath, \{Meagan J.\} and Suzie Verma and Vanesa Tomatis and Acharya, \{Bipul R.\} and Lakshmi Balasubramaniam and Templin, \{Rachel M.\} and McMahon, \{Kerrie Ann\} and Lee, \{Yoke Seng\} and Ju, \{Robert J.\} and Stebhens, \{Samantha J.\} and Benoit Ladoux and Mitchell, \{Christina A.\} and Collins, \{Brett M.\} and Parton, \{Robert G.\} and Yap, \{Alpha S.\}",

year = "2020",

month = jul,

day = "6",

doi = "10.1016/j.devcel.2020.05.002",

language = "English",

volume = "54",

pages = "75--91",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

}

Teo, JL, Gomez, GA, Weeratunga, S, Davies, EM, Noordstra, I, Budnar, S, Katsuno-Kambe, H, McGrath, MJ, Verma, S, Tomatis, V, Acharya, BR, Balasubramaniam, L, Templin, RM, McMahon, KA, Lee, YS, Ju, RJ, Stebhens, SJ, Ladoux, B, Mitchell, CA, Collins, BM, Parton, RG & Yap, AS 2020, 'Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells', Developmental Cell, vol. 54, pp. 75-91. https://doi.org/10.1016/j.devcel.2020.05.002

TY - JOUR

T1 - Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells

AU - Teo, Jessica L.

AU - Gomez, Guillermo A.

AU - Weeratunga, Saroja

AU - Davies, Elizabeth M.

AU - Noordstra, Ivar

AU - Budnar, Srikanth

AU - Katsuno-Kambe, Hiroko

AU - McGrath, Meagan J.

AU - Verma, Suzie

AU - Tomatis, Vanesa

AU - Acharya, Bipul R.

AU - Balasubramaniam, Lakshmi

AU - Templin, Rachel M.

AU - McMahon, Kerrie Ann

AU - Lee, Yoke Seng

AU - Ju, Robert J.

AU - Stebhens, Samantha J.

AU - Ladoux, Benoit

AU - Mitchell, Christina A.

AU - Collins, Brett M.

AU - Parton, Robert G.

AU - Yap, Alpha S.

PY - 2020/7/6

Y1 - 2020/7/6

N2 - Teo et al. report that caveolae can regulate epithelial contractility by lipid signaling. Caveolin-1 depletion enhanced phosphoinositide-4,5- bisphosphate (PtdIns(4,5)P2) levels to recruit FMNL2, which stabilizes F-actin and increases tension at adherens junctions. Elevated epithelial tension disrupts the elimination of oncogene-expressing cells by apical extrusion.

AB - Teo et al. report that caveolae can regulate epithelial contractility by lipid signaling. Caveolin-1 depletion enhanced phosphoinositide-4,5- bisphosphate (PtdIns(4,5)P2) levels to recruit FMNL2, which stabilizes F-actin and increases tension at adherens junctions. Elevated epithelial tension disrupts the elimination of oncogene-expressing cells by apical extrusion.

KW - actomyosin

KW - caveolae

KW - epithelial tension

KW - extrusion

KW - phosphoinositides

UR - https://www.scopus.com/pages/publications/85086662343

U2 - 10.1016/j.devcel.2020.05.002

DO - 10.1016/j.devcel.2020.05.002

M3 - Article

C2 - 32485139

AN - SCOPUS:85086662343

SN - 1534-5807

VL - 54

SP - 75

EP - 91

JO - Developmental Cell

JF - Developmental Cell

ER -

Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells

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Keywords

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Translating membrane proteins into therapeutics; from bedside to bench

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Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells

Abstract

Keywords

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Translating membrane proteins into therapeutics; from bedside to bench

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