Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells

Jessica L. Teo, Guillermo A. Gomez, Saroja Weeratunga, Elizabeth M. Davies, Ivar Noordstra, Srikanth Budnar, Hiroko Katsuno-Kambe, Meagan J. McGrath, Suzie Verma, Vanesa Tomatis, Bipul R. Acharya, Lakshmi Balasubramaniam, Rachel M. Templin, Kerrie Ann McMahon, Yoke Seng Lee, Robert J. Ju, Samantha J. Stebhens, Benoit Ladoux, Christina A. Mitchell, Brett M. CollinsRobert G. Parton, Alpha S. Yap

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)


Teo et al. report that caveolae can regulate epithelial contractility by lipid signaling. Caveolin-1 depletion enhanced phosphoinositide-4,5- bisphosphate (PtdIns(4,5)P2) levels to recruit FMNL2, which stabilizes F-actin and increases tension at adherens junctions. Elevated epithelial tension disrupts the elimination of oncogene-expressing cells by apical extrusion.

Original languageEnglish
Pages (from-to)75-91
Number of pages18
JournalDevelopmental Cell
Publication statusPublished - 6 Jul 2020


  • actomyosin
  • caveolae
  • epithelial tension
  • extrusion
  • phosphoinositides

Cite this

Teo, J. L., Gomez, G. A., Weeratunga, S., Davies, E. M., Noordstra, I., Budnar, S., Katsuno-Kambe, H., McGrath, M. J., Verma, S., Tomatis, V., Acharya, B. R., Balasubramaniam, L., Templin, R. M., McMahon, K. A., Lee, Y. S., Ju, R. J., Stebhens, S. J., Ladoux, B., Mitchell, C. A., ... Yap, A. S. (2020). Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells. Developmental Cell, 54, 75-91.