Teo et al. report that caveolae can regulate epithelial contractility by lipid signaling. Caveolin-1 depletion enhanced phosphoinositide-4,5- bisphosphate (PtdIns(4,5)P2) levels to recruit FMNL2, which stabilizes F-actin and increases tension at adherens junctions. Elevated epithelial tension disrupts the elimination of oncogene-expressing cells by apical extrusion.
- epithelial tension