Caveolae and caveolin in immune cells: Distribution and functions

James Harris; Dirk Werling; Jayne C. Hope; Geraldine Taylor; Chris J. Howard

doi:10.1016/S1471-4906(01)02161-5

Caveolae and caveolin in immune cells: Distribution and functions

James Harris, Dirk Werling, Jayne C. Hope, Geraldine Taylor, Chris J. Howard

Research output: Contribution to journal › Review Article › Research › peer-review

134 Citations (Scopus)

Abstract

Caveolae are small, cholesterol-rich, hydrophobic membrane domains, characterized by the presence of the protein caveolin and involved in several cellular processes, including clathrin-independent endocytosis, the regulation and transport of cellular cholesterol, and signal transduction. Recently, caveolae have been identified as providing a novel route by which several pathogens are internalized by antigen-presenting cells and as centers for signal transduction. Here, we review the distribution and role of caveolae and caveolin in mammalian immune cells.

Original language	English
Pages (from-to)	158-164
Number of pages	7
Journal	Trends in Immunology
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/S1471-4906(01)02161-5
Publication status	Published - 1 Mar 2002
Externally published	Yes

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title = "Caveolae and caveolin in immune cells: Distribution and functions",

abstract = "Caveolae are small, cholesterol-rich, hydrophobic membrane domains, characterized by the presence of the protein caveolin and involved in several cellular processes, including clathrin-independent endocytosis, the regulation and transport of cellular cholesterol, and signal transduction. Recently, caveolae have been identified as providing a novel route by which several pathogens are internalized by antigen-presenting cells and as centers for signal transduction. Here, we review the distribution and role of caveolae and caveolin in mammalian immune cells.",

author = "James Harris and Dirk Werling and Hope, \{Jayne C.\} and Geraldine Taylor and Howard, \{Chris J.\}",

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T1 - Caveolae and caveolin in immune cells

T2 - Distribution and functions

AU - Harris, James

AU - Werling, Dirk

AU - Hope, Jayne C.

AU - Taylor, Geraldine

AU - Howard, Chris J.

PY - 2002/3/1

Y1 - 2002/3/1

N2 - Caveolae are small, cholesterol-rich, hydrophobic membrane domains, characterized by the presence of the protein caveolin and involved in several cellular processes, including clathrin-independent endocytosis, the regulation and transport of cellular cholesterol, and signal transduction. Recently, caveolae have been identified as providing a novel route by which several pathogens are internalized by antigen-presenting cells and as centers for signal transduction. Here, we review the distribution and role of caveolae and caveolin in mammalian immune cells.

AB - Caveolae are small, cholesterol-rich, hydrophobic membrane domains, characterized by the presence of the protein caveolin and involved in several cellular processes, including clathrin-independent endocytosis, the regulation and transport of cellular cholesterol, and signal transduction. Recently, caveolae have been identified as providing a novel route by which several pathogens are internalized by antigen-presenting cells and as centers for signal transduction. Here, we review the distribution and role of caveolae and caveolin in mammalian immune cells.

UR - https://www.scopus.com/pages/publications/0036498556

U2 - 10.1016/S1471-4906(01)02161-5

DO - 10.1016/S1471-4906(01)02161-5

M3 - Review Article

C2 - 11864845

AN - SCOPUS:0036498556

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VL - 23

SP - 158

EP - 164

JO - Trends in Immunology

JF - Trends in Immunology

IS - 3

ER -

Caveolae and caveolin in immune cells: Distribution and functions

Abstract

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