Caveolae and caveolin in immune cells: Distribution and functions

James Harris, Dirk Werling, Jayne C. Hope, Geraldine Taylor, Chris J. Howard

Research output: Contribution to journalReview ArticleResearchpeer-review

118 Citations (Scopus)

Abstract

Caveolae are small, cholesterol-rich, hydrophobic membrane domains, characterized by the presence of the protein caveolin and involved in several cellular processes, including clathrin-independent endocytosis, the regulation and transport of cellular cholesterol, and signal transduction. Recently, caveolae have been identified as providing a novel route by which several pathogens are internalized by antigen-presenting cells and as centers for signal transduction. Here, we review the distribution and role of caveolae and caveolin in mammalian immune cells.

Original languageEnglish
Pages (from-to)158-164
Number of pages7
JournalTrends in Immunology
Volume23
Issue number3
DOIs
Publication statusPublished - 1 Mar 2002
Externally publishedYes

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