TY - JOUR
T1 - Caveolae and caveolin in immune cells
T2 - Distribution and functions
AU - Harris, James
AU - Werling, Dirk
AU - Hope, Jayne C.
AU - Taylor, Geraldine
AU - Howard, Chris J.
PY - 2002/3/1
Y1 - 2002/3/1
N2 - Caveolae are small, cholesterol-rich, hydrophobic membrane domains, characterized by the presence of the protein caveolin and involved in several cellular processes, including clathrin-independent endocytosis, the regulation and transport of cellular cholesterol, and signal transduction. Recently, caveolae have been identified as providing a novel route by which several pathogens are internalized by antigen-presenting cells and as centers for signal transduction. Here, we review the distribution and role of caveolae and caveolin in mammalian immune cells.
AB - Caveolae are small, cholesterol-rich, hydrophobic membrane domains, characterized by the presence of the protein caveolin and involved in several cellular processes, including clathrin-independent endocytosis, the regulation and transport of cellular cholesterol, and signal transduction. Recently, caveolae have been identified as providing a novel route by which several pathogens are internalized by antigen-presenting cells and as centers for signal transduction. Here, we review the distribution and role of caveolae and caveolin in mammalian immune cells.
UR - http://www.scopus.com/inward/record.url?scp=0036498556&partnerID=8YFLogxK
U2 - 10.1016/S1471-4906(01)02161-5
DO - 10.1016/S1471-4906(01)02161-5
M3 - Review Article
C2 - 11864845
AN - SCOPUS:0036498556
VL - 23
SP - 158
EP - 164
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 3
ER -