TY - JOUR
T1 - Caveolae
T2 - A role in endothelial inflammation and mechanotransduction?
AU - Shihata, Waled A.
AU - Michell, Danielle L.
AU - Andrews, Karen L.
AU - Chin-Dusting, Jaye P. F.
PY - 2016/12/20
Y1 - 2016/12/20
N2 - Vascular inflammation and disease progression, such as atherosclerosis, are in part a consequence of haemodynamic forces generated by changes in blood flow. The haemodynamic forces, such as shear stress or stretch, interact with vascular endothelial cells, which transduce the mechanical stimuli into biochemical signals via mechanosensors, which can induce an upregulation in pathways involved in inflammatory signaling. However, it is unclear how these mechanosensors respond to shear stress and most significantly what cellular mechanisms are involved in sensing the haemodynamic stimuli. This review explores the transition from shear forces, stretch and pressure to endothelial inflammation and the process of mechanotransduction, specifically highlighting evidence to suggest that caveolae play as a role as mechanosensors.
AB - Vascular inflammation and disease progression, such as atherosclerosis, are in part a consequence of haemodynamic forces generated by changes in blood flow. The haemodynamic forces, such as shear stress or stretch, interact with vascular endothelial cells, which transduce the mechanical stimuli into biochemical signals via mechanosensors, which can induce an upregulation in pathways involved in inflammatory signaling. However, it is unclear how these mechanosensors respond to shear stress and most significantly what cellular mechanisms are involved in sensing the haemodynamic stimuli. This review explores the transition from shear forces, stretch and pressure to endothelial inflammation and the process of mechanotransduction, specifically highlighting evidence to suggest that caveolae play as a role as mechanosensors.
KW - Blood pressure
KW - Caveolae (or caveolin-1)
KW - Endothelial cells
KW - Haemodynamics
KW - Inflammation
KW - Mechanotransduction
UR - http://www.scopus.com/inward/record.url?scp=85009412377&partnerID=8YFLogxK
U2 - 10.3389/fphys.2016.00628
DO - 10.3389/fphys.2016.00628
M3 - Review Article
AN - SCOPUS:85009412377
VL - 7
JO - Frontiers in Physiology
JF - Frontiers in Physiology
SN - 1664-042X
M1 - 628
ER -