Catecholamine Modulation of Evidence Accumulation during Perceptual Decision Formation

A Randomized Trial

Gerard M. Loughnane, Meadhbh B. Brosnan, Jessica J. M. Barnes, Angela Dean, Sanjay L. Nandam, Redmond G. O'Connell, Mark A. Bellgrove

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Recent behavioral modeling and pupillometry studies suggest that neuromodulatory arousal systems play a role in regulating decision formation but neurophysiological support for these observations is lacking. We employed a randomized, double-blinded, placebo-controlled, crossover design to probe the impact of pharmacological enhancement of catecholamine levels on perceptual decision-making. Catecholamine levels were manipulated using the clinically relevant drugs methylphenidate and atomoxetine, and their effects were compared with those of citalopram and placebo. Participants performed a classic EEG oddball paradigm that elicits the P3b, a centro-parietal potential that has been shown to trace evidence accumulation, under each of the four drug conditions. We found that methylphenidate and atomoxetine administration shortened RTs to the oddball targets. The neural basis of this behavioral effect was an earlier P3b peak latency, driven specifically by an increase in its buildup rate without any change in its time of onset or peak amplitude. This study provides neurophysiological evidence for the catecholaminergic enhancement of a discrete aspect of human decision-making, that is, evidence accumulation. Our results also support theoretical accounts suggesting that catecholamines may enhance cognition via increases in neural gain.
Original languageEnglish
Pages (from-to)1044-1053
Number of pages10
JournalJournal of Cognitive Neuroscience
Volume31
Issue number7
DOIs
Publication statusPublished - Jul 2019

Cite this

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title = "Catecholamine Modulation of Evidence Accumulation during Perceptual Decision Formation: A Randomized Trial",
abstract = "Recent behavioral modeling and pupillometry studies suggest that neuromodulatory arousal systems play a role in regulating decision formation but neurophysiological support for these observations is lacking. We employed a randomized, double-blinded, placebo-controlled, crossover design to probe the impact of pharmacological enhancement of catecholamine levels on perceptual decision-making. Catecholamine levels were manipulated using the clinically relevant drugs methylphenidate and atomoxetine, and their effects were compared with those of citalopram and placebo. Participants performed a classic EEG oddball paradigm that elicits the P3b, a centro-parietal potential that has been shown to trace evidence accumulation, under each of the four drug conditions. We found that methylphenidate and atomoxetine administration shortened RTs to the oddball targets. The neural basis of this behavioral effect was an earlier P3b peak latency, driven specifically by an increase in its buildup rate without any change in its time of onset or peak amplitude. This study provides neurophysiological evidence for the catecholaminergic enhancement of a discrete aspect of human decision-making, that is, evidence accumulation. Our results also support theoretical accounts suggesting that catecholamines may enhance cognition via increases in neural gain.",
author = "Loughnane, {Gerard M.} and Brosnan, {Meadhbh B.} and Barnes, {Jessica J. M.} and Angela Dean and Nandam, {Sanjay L.} and O'Connell, {Redmond G.} and Bellgrove, {Mark A.}",
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Catecholamine Modulation of Evidence Accumulation during Perceptual Decision Formation : A Randomized Trial. / Loughnane, Gerard M.; Brosnan, Meadhbh B.; Barnes, Jessica J. M.; Dean, Angela; Nandam, Sanjay L.; O'Connell, Redmond G.; Bellgrove, Mark A.

In: Journal of Cognitive Neuroscience, Vol. 31, No. 7, 07.2019, p. 1044-1053.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Loughnane, Gerard M.

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AU - Dean, Angela

AU - Nandam, Sanjay L.

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AU - Bellgrove, Mark A.

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AB - Recent behavioral modeling and pupillometry studies suggest that neuromodulatory arousal systems play a role in regulating decision formation but neurophysiological support for these observations is lacking. We employed a randomized, double-blinded, placebo-controlled, crossover design to probe the impact of pharmacological enhancement of catecholamine levels on perceptual decision-making. Catecholamine levels were manipulated using the clinically relevant drugs methylphenidate and atomoxetine, and their effects were compared with those of citalopram and placebo. Participants performed a classic EEG oddball paradigm that elicits the P3b, a centro-parietal potential that has been shown to trace evidence accumulation, under each of the four drug conditions. We found that methylphenidate and atomoxetine administration shortened RTs to the oddball targets. The neural basis of this behavioral effect was an earlier P3b peak latency, driven specifically by an increase in its buildup rate without any change in its time of onset or peak amplitude. This study provides neurophysiological evidence for the catecholaminergic enhancement of a discrete aspect of human decision-making, that is, evidence accumulation. Our results also support theoretical accounts suggesting that catecholamines may enhance cognition via increases in neural gain.

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