Catalytic enantioselective tandem carbonyl ylide formation-cycloaddition

David M. Hodgson, Paul A. Stupple, Craig Johnstone

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Abstract

Catalytic enantioselective tandem carbonyl ylide formation-cycloaddition of α-diazo-β-ketoesters 1 (R = alkyl, n = 1,2) using 1 mol% [Rh2(S-DOSP)4] 2 in hexane at room temperature to give the cycloadducts 3 in good yields and up to 53% ee are described.

Original languageEnglish
Pages (from-to)6471-6472
Number of pages2
JournalTetrahedron Letters
Volume38
Issue number36
DOIs
Publication statusPublished - 8 Sep 1997
Externally publishedYes

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