Ca2+ oscillations at fertilization in mammals

G. Halet, P. Marangos, G. FitzHarris, J. Carroll

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26 Citations (Scopus)


The mouse egg provided the first direct measurement of Ca2+ oscillations in any cell type. These sperm-induced Ca2+ oscillations occur at a relatively low frequency, and can be detected up to 18-20 h after sperm-egg fusion. The Ca2+ oscillations consist of two series of transients; the first lasts about 4 h, from metaphase II until interphase of the first cell cycle, and the second lasts the duration of the first mitotic division. This cell-cycle-regulated aspect to the pattern of Ca2+ signalling at fertilization is reflected in the role of the Ca2+ transients in stimulating exit from metaphase arrest. Recent developments have started to shed light on the mechanism initiating Ca2+ oscillations at fertilization, on how the frequency of the oscillations is set, and on what determines their temporal pattern.

Original languageEnglish
Pages (from-to)907-911
Number of pages5
JournalBiochemical Society Transactions
Issue number5
Publication statusPublished - 1 Jan 2003
Externally publishedYes


  • Cell cycle
  • Fertilization
  • Green fluorescent protein
  • Nucleus
  • Phospholipase C
  • Protein kinase C (PKC)
  • Sperm

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