Caspases

J. Puccini, S. Kumar

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)

Abstract

Caspases constitute the effector arm of the apoptotic machinery. They are a family of cysteine aspartyl proteases, which when activated cleave many hundreds of cellular proteins to bring about the ordered dismantling of the cells dying by apoptosis. In addition to apoptosis, some caspases have other functions, including in different modalities of cell death, inflammation, proliferation, and differentiation. This article summarizes the key aspects of the biochemistry and biological functions of caspases.

Original languageEnglish
Title of host publicationEncyclopedia of Cell Biology
PublisherElsevier
Pages364-373
Number of pages10
Volume3
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Apoptosis
  • Apoptosome
  • Caspases
  • Death-induced signaling complex
  • Inflammasome
  • Inflammation
  • Necroptosis
  • Programed cell death
  • Pyroptosis

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