Caspases constitute the effector arm of the apoptotic machinery. They are a family of cysteine aspartyl proteases, which when activated cleave many hundreds of cellular proteins to bring about the ordered dismantling of the cells dying by apoptosis. In addition to apoptosis, some caspases have other functions, including in different modalities of cell death, inflammation, proliferation, and differentiation. This article summarizes the key aspects of the biochemistry and biological functions of caspases.
|Title of host publication||Encyclopedia of Cell Biology|
|Number of pages||10|
|Publication status||Published - 2016|
- Death-induced signaling complex
- Programed cell death