@article{baa375d788e946559f675352295360ce,
title = "Carvedilol and cardiac biomarkers in dialysis patients: Secondary analysis of a randomized controlled trial",
abstract = "Background/Aims: Cardiac biomarkers are associated with cardiac abnormalities and adverse outcomes in dialysis patients. Our aim was to report the effect of the beta-blocker carvedilol on cardiac biomarkers in adult dialysis patients. Methods: The Beta-Blocker to Lower Cardiovascular Dialysis Events Feasibility Study was a randomized controlled trial comparing carvedilol to placebo. Serum and plasma were collected before the run-in, then 6 and 12 months post-randomization to measure B-type Natriuretic Peptide (BNP), N-terminal BNP (NT-ProBNP), high-sensitivity cardiac troponins I (hs-TnI) and T (hs-TnT), and galectin-3. Left ventricular global longitudinal strain (GLS) was measured by echocardiography at baseline. Results: Seventy-two participants were recruited of whom 49 completed the run-in and were randomized to carvedilol (n=26) or placebo (n=23). Baseline echocardiography demonstrated median (inter-quartile range) GLS of -14.27\% (-16.63 to -11.93). NTproBNP and hs-TnT correlated with GLS (Spearman's rho=0.34 [p=0.018] and rho=0.28 [p=0.049], respectively). Median change scores from baseline to 12 months did not differ significantly between participants with complete biomarker data randomized to carvedilol (n=15) or placebo (n=16) for any biomarkers. Conclusions: NT-proBNP and hs-TnT were associated with GLS. However, changes in levels of the biomarkers from baseline to 12 months were not different between groups randomized to carvedilol and placebo.",
keywords = "Beta-adrenergic receptor blocker, Cardiac biomarkers, Cardiovascular, Dialysis, Echocardiography, Randomized controlled trial",
author = "Roberts, \{Matthew A.\} and Darsy Darssan and Badve, \{Sunil V.\} and Carroll, \{Robert P.\} and Fahim, \{Magid A.\} and Haluska, \{Brian A.\} and Hawley, \{Carmel M.\} and Isbel, \{Nicole M.\} and Marshall, \{Mark R.\} and Pascoe, \{Elaine M.\} and Eugenie Pedagogos and Pilmore, \{Helen L.\} and Paul Snelling and Tony Stanton and Tan, \{Ken Soon\} and Tonkin, \{Andrew M.\} and Vergara, \{Liza A.\} and Ierino, \{Francesco L.\}",
note = "Funding Information: The BLOCADE Feasibility Study was supported by a Don \& Lorraine Jacquot Collaborative Research Initiative Grant (2008), a New Zealand Health Research Council Feasibility Study Grant (10-163), and a National Health and Medical Research Council (NHMRC) Project Grant (1006171). Roche Products, Pty Limited provided Dilatrend{\textregistered} at a discounted price. Funding from a P 퀀izer CVL ( 球爃爃稂I grant funded the assays for the biomarkers. Assay materials for galectin-3, hs-TnI and BNP were provided by Abbott Laboratories. Dr Roberts was supported by a NHMRC Training Fellowship (628902). Trial Steering Committee: Matthew A Roberts (Chair), Department of Renal Medicine, Eastern Health Clinical School, Monash University, Melbourne, Australia; Alan Cass, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia; Amit X Garg, Division of Nephrology, Department of Medicine, Western University, London, Canada; Carmel M Hawley, Australasian Kidney Trials Network, The University of Queensland, Brisbane; Francesco L Ierino, Department of Nephrology, Austin Health, Melbourne, Australia; Nicole M Isbel, Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia; Henry Krum, Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia; Elaine M Pascoe, Australasian Kidney Trials Network, The University of Queensland, Brisbane, Australia; Vlado Perkovic, The George Institute for Global Health, Sydney, Australia; Helen L Pilmore, Department of Renal Medicine, Auckland City Hospital, Auckland, New Zealand; Andrew M Tonkin, Cardiovascular Research Unit, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia; Liza A Vergara, Australasian Kidney Trials Network, The University of Queensland, Brisbane, Australia Data Safety Monitoring Board: Adeera Levin (Chair), Department of Medicine, University of British Columbia, Vancouver, Canada; David Hare, Cardiology Department, Austin Health, University of Melbourne, Melbourne, Australia; Andrew Martin, NHMRC Clinical Trials Centre University of Sydney, Sydney, Australia; David C Wheeler, Centre for Nephrology, Division of Medicine, University College London, United Kingdom. Endpoint Adjudication Committee: Gregory Fulcher (Chair), Royal North Shore Hospital, Sydney, Australia; Helen Brown, Princess Alexandra Hospital, Brisbane, Australia; David Colquhoun, Wesley Medical Centre, Brisbane, Australia; Dariusz Korczyk, Princess Alexandra Hospital, Brisbane, Australia; Amanda Mather, Royal North Shore Hospital, Sydney, Australia; Andrew Wong, Royal Brisbane and Women{\textquoteright}s Hospital, Brisbane, Australia Investigators (Site Investigators): Australian sites: Austin Health (Matthew Roberts, Francesco Ierino, Pascal Bisscheroux), John Hunter Hospital (Alastair Gillies, Leanne Garvey), Logan Hospital (Ken-Soon Tan, Erica Lennan), Princess Alexandra Hospital (Nicole Isbel, Markus Pitkin, Karin Ahearn), Royal Adelaide Hospital (Robert P Carroll, Eileen Scott), Royal North Shore Hospital (Bruce Cooper, Jacqueline Pearse), Royal Prince Alfred Hospital (Paul Snelling, Jenny Burman, Samantha Hand), Royal Melbourne Hospital (Eugenie Pedagogos, Connie Karschimkus); New Zealand sites: Auckland City Hospital (Helen Pilmore, Andrew Pilmore); Dunedin Hospital (Robert Walker, Gaye Ellis), Middlemore Hospital (Mark R Marshall, Cecilia Paul) Project Management Team: Australasian Kidney Trials Network, Brisbane, Queensland, Australia: Carmel M Hawley (Chair, AKTN Operations Secretariat), David Johnson (Deputy Chair, AKTN Operations Secretariat), Sunil Badve, Alan Cass, Darsy Darssan, Jean Helyar, Alicia Morrish, Elaine M Pascoe, Peta-Anne Paul-Brent, Donna Reidlinger, Anish Scaria, Liza A Vergara and Lei Zhang. Publisher Copyright: {\textcopyright} 2017 The Author(s) Published by S. Karger AG, Basel",
year = "2017",
doi = "10.1159/000485589",
language = "English",
volume = "42",
pages = "1033--1044",
journal = "Kidney and Blood Pressure Research",
issn = "1420-4096",
publisher = "S Karger AG",
number = "6",
}