Carnosine and the processes of ageing

Alan R. Hipkiss, Estifanos Baye, Barbora de Courten

Research output: Contribution to journalReview ArticleOtherpeer-review

12 Citations (Scopus)

Abstract

The causes of ageing are usually regarded as multifactorial; thus effective regulation might be achieved by intervention at multiple sites. It has been suggested that the endogenous dipeptide carnosine, also available as a food supplement, possesses anti-ageing activity and may achieve its reported age-alleviating effects via a number of mechanisms. Carnosine's possible anti-ageing mechanisms are therefore discussed; the evidence suggests that inhibition of the mechanistic target of rapamycin and carbonyl scavenging may be involved.

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalMaturitas
Volume93
DOIs
Publication statusPublished - 1 Nov 2016

Keywords

  • Advanced glycation end products
  • Ageing
  • Carnosine
  • Inflammation
  • Oxidative stress
  • Signalling pathways

Cite this

Hipkiss, Alan R. ; Baye, Estifanos ; de Courten, Barbora. / Carnosine and the processes of ageing. In: Maturitas. 2016 ; Vol. 93. pp. 28-33.
@article{38e72e6155dd479995f3bc28d5b135c5,
title = "Carnosine and the processes of ageing",
abstract = "The causes of ageing are usually regarded as multifactorial; thus effective regulation might be achieved by intervention at multiple sites. It has been suggested that the endogenous dipeptide carnosine, also available as a food supplement, possesses anti-ageing activity and may achieve its reported age-alleviating effects via a number of mechanisms. Carnosine's possible anti-ageing mechanisms are therefore discussed; the evidence suggests that inhibition of the mechanistic target of rapamycin and carbonyl scavenging may be involved.",
keywords = "Advanced glycation end products, Ageing, Carnosine, Inflammation, Oxidative stress, Signalling pathways",
author = "Hipkiss, {Alan R.} and Estifanos Baye and {de Courten}, Barbora",
year = "2016",
month = "11",
day = "1",
doi = "10.1016/j.maturitas.2016.06.002",
language = "English",
volume = "93",
pages = "28--33",
journal = "Maturitas",
issn = "0378-5122",
publisher = "Elsevier",

}

Carnosine and the processes of ageing. / Hipkiss, Alan R.; Baye, Estifanos; de Courten, Barbora.

In: Maturitas, Vol. 93, 01.11.2016, p. 28-33.

Research output: Contribution to journalReview ArticleOtherpeer-review

TY - JOUR

T1 - Carnosine and the processes of ageing

AU - Hipkiss, Alan R.

AU - Baye, Estifanos

AU - de Courten, Barbora

PY - 2016/11/1

Y1 - 2016/11/1

N2 - The causes of ageing are usually regarded as multifactorial; thus effective regulation might be achieved by intervention at multiple sites. It has been suggested that the endogenous dipeptide carnosine, also available as a food supplement, possesses anti-ageing activity and may achieve its reported age-alleviating effects via a number of mechanisms. Carnosine's possible anti-ageing mechanisms are therefore discussed; the evidence suggests that inhibition of the mechanistic target of rapamycin and carbonyl scavenging may be involved.

AB - The causes of ageing are usually regarded as multifactorial; thus effective regulation might be achieved by intervention at multiple sites. It has been suggested that the endogenous dipeptide carnosine, also available as a food supplement, possesses anti-ageing activity and may achieve its reported age-alleviating effects via a number of mechanisms. Carnosine's possible anti-ageing mechanisms are therefore discussed; the evidence suggests that inhibition of the mechanistic target of rapamycin and carbonyl scavenging may be involved.

KW - Advanced glycation end products

KW - Ageing

KW - Carnosine

KW - Inflammation

KW - Oxidative stress

KW - Signalling pathways

UR - http://www.scopus.com/inward/record.url?scp=84991672210&partnerID=8YFLogxK

U2 - 10.1016/j.maturitas.2016.06.002

DO - 10.1016/j.maturitas.2016.06.002

M3 - Review Article

VL - 93

SP - 28

EP - 33

JO - Maturitas

JF - Maturitas

SN - 0378-5122

ER -